Measurement of nitric oxide in human exhaled breath
- Battelle Memorial Institute, Columbus, OH (United States)
- American Petroleum Institute, Washington, DC (United States)
This project was initiated to confirm the reliability of nitric oxide (NO) measurement in the breath matrix, using two different analytical techniques - ozone and luminol chemiluminescence - and to corroborate literature reports of elevated breath NO values. To measure peak oral and nasal NO levels, subjects performed slow vital capacity and breath holding maneuvers directly into the monitors through the mouth and the nose, respectively. Additional measurements were made using normal breathing techniques. Initial interferent tests indicate that measured NO signals are real and are not confounded by measurement artifacts. Similar results were obtained using the two independent analytical methods in dry or humid air. The NO signal was unaffected by maximum concentrations of potential breath interferents, such as sulfur compounds and alkenes. The measured breath NO concentrations were greater than typical room air levels and differed significantly with the breathing technique used. During these tests room air averaged 4-5 ppb NO. Peak oral NO levels were 4.3 {+-} 1.5 ppb during a slow vital capacity maneuver and 8.0 {+-} 5.0 ppb during a breath holding maneuver. By contrast, higher peak nasal NO levels were measured for both slow vital capacity (17.8 {+-} 7.8 ppb) and breath holding maneuvers (45.4 {+-} 29.5 ppb).
- OSTI ID:
- 617802
- Report Number(s):
- CONF-9704195-; TRN: 98:002116-0053
- Resource Relation:
- Conference: Specialty conference on measurement of toxic and related air pollutants, Research Triangle Park, NC (United States), 29 Apr - 1 May 1997; Other Information: PBD: 1997; Related Information: Is Part Of Measurement of toxic and related air pollutants. Volume 1 and 2; PB: 1004 p.
- Country of Publication:
- United States
- Language:
- English
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