Myocardial accumulation of iodinated beta-methyl-branched fatty acid analogue, iodine-125-15-(p-iodophenyl)-3-(R,S)methylpentadecanoic acid (BMIPP), in relation to ATP concentration

Journal Article · Thu Nov 01 00:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6169588

Fujibayashi, Y; Yonekura, Y; Takemura, Y; Wada, K; Matsumoto, K; Tamaki, N; Yamamoto, K; Konishi, J; Yokoyama, A ^[1]

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1. Kyoto Univ. (Japan)

To clarify the relationship between the myocardial accumulation of {sup 125}I-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) and intracellular adenosine-5'-triphosphate (ATP) content, the effect of 2,4-dinitrophenol (DNP, an electron transport uncoupler) on myocardial BMIPP accumulation was studied, in comparison with that of thallium-201-chloride ({sup 201}Tl-Cl). In the mouse myocardium, DNP decreased the intracellular ATP and ADP levels, without affecting either acyl-CoA synthetase activity or the level of CoA-SH. Following treatment with DNP, decreases in myocardial BMIPP accumulation correlated well with those of ATP, while {sup 201}Tl-Cl showed slightly increased accumulation in the myocardium. Thus, in some diseases, BMIPP may be useful in evaluating myocardial ATP levels.

• OSTI ID: 6169588
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:11; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NITRO COMPOUNDS
BIOLOGICAL EFFECTS
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
ADP
ATP
COENZYMES
COMPARATIVE EVALUATIONS
ELECTROPHORESIS
ENZYME ACTIVITY
IODINE 125
LIGASES
METABOLISM
MYOCARDIUM
PHENOLS
THALLIUM 201
AROMATICS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
HEART
HEAVY NUCLEI
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MUSCLES
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560300 - Chemicals Metabolism & Toxicology