Salinomycin residues and their ionophoricity in pig tissues
- A.H. Robins Co., Richmond, VA (USA)
- Hill Top Pharmatest, Inc. Cincinnati, OH (USA)
- Analytical Development Corp., Colorado Springs, CO (USA)
- Colorado State Univ., Fort Collins (USA)
The effect of pretreatment with medicated feed on ({sup 14}C) salinomycin residue levels in pig tissues was studied. Pigs were fed unmedicated feed or feed medicated with salinomycin at 41 ppm in the diet for 29 days and then dosed with ({sup 14}C)salinomycin for 8 days. Total drug residue levels were below quantifiable limits of detection of kidney, fat, and muscle but at the tolerance limit of 1,800 ppb for liver. In liver, pretreatment tended to lower total residue levels, and unchanged ({sup 14}C)salinomycin accounted for <1% of the total drug residue. Approximately 15-20% of the total drug residue in liver was bound. Ionophoric activity in extracts of livers from the treated pigs was minimal, and only 2 of the 12 treated samples had ionophoric activity more than twice that obtained from the controls.
- OSTI ID:
- 6168478
- Journal Information:
- Journal of Agricultural and Food Chemistry; (USA), Vol. 38:4; ISSN 0021-8561
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ANIMAL FEEDS
ANTIBIOTICS
METABOLISM
AGRICULTURE
CARBON 14
RESIDUES
SWINE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
ANIMALS
ANTI-INFECTIVE AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBON ISOTOPES
DISTRIBUTION
DOMESTIC ANIMALS
DRUGS
EVEN-EVEN NUCLEI
FOOD
INDUSTRY
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
NUCLEI
RADIOISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
553000* - Agriculture & Food Technology
550501 - Metabolism- Tracer Techniques