DNA damage and radiosensitizers: M. luteus sensitive sites for misonidazole-TAN combination
It has been shown previously that TAN does not enhance production of single-strand breaks (SSB) in DNA of Chinese hamster cells irradiated under hypoxia. In contrast, misonidazole does enhance the yield of SSB, but this SSB enhancement by misonidazole is reduced if TAN is present with misonidazole during irradiation. It was also shown that each of these sensitizers enhances base/sugar damage, measured with the aid of bacterial enzymes (MLS). The results presented here for MLS damage in mammalian cells irradiated in the presence of the misonidazole-TAN combination indicate that the two drugs act independently in enhancing MLS damage, and hence they interact with different types of lesions to produce base/sugar damage. It is proposed that the protection by TAN in mammalian cells observed at the survival level is due to repair of some of that type of damage which would otherwise become a misonidazole-enhanced SSB.
- Research Organization:
- British Columbia Cancer Research Center, Vancouver, Canada
- OSTI ID:
- 6163557
- Journal Information:
- Radiat. Res.; (United States), Vol. 92:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MICROCOCCUS LUTEUS
BIOLOGICAL RADIATION EFFECTS
MISONIDAZOLE
RADIOSENSITIVITY EFFECTS
STRAND BREAKS
RADIOINDUCTION
TAN
BIOLOGICAL REPAIR
DNA
GAMMA RADIATION
AMINES
ANTINEOPLASTIC DRUGS
AZINES
AZOLES
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
KETONES
MICROCOCCUS
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PIPERIDINES
PYRIDINES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIZERS
RECOVERY
REPAIR
560112* - Radiation Effects on Biochemicals- In Microorganisms- (-1987)
560131 - Radiation Effects on Microorganisms- Basic Studies- (-1987)