Unstable cellular differentiation in adenosquamous cell carcinoma
For the determination of whether two or more stem lines with fixed or stable differentiation are present in a growing mixed adenosquamous cell carcinoma, two different mixed tumors, derived from transformed F344 rat tracheal epithelium, were dissociated and ten single cells were isolated from each tumor. All clones were then inoculated into animals for the assessment of in vivo differentiation. Of the ten single cell clones isolated from the first tumor, seven clones produced mixed adenosquamous carcinomas and three produced adenocarcinomas in which no squamous cell component was found. From the second tumor, eight clones produced mixed tumors and two produced squamous cell carcinomas in which no adenocarcinoma component was found. These studies strongly suggest that the mixture of differentiated cell types in adenosquamous cell carcinomas is not the result of a mixture of stem cells with one fixed phenotype within the tumor, but rather is the result of an instability of differentiation; the neoplastic cells can express both types of differentiation.
- Research Organization:
- National Inst. of Environmental Health Sciences, Research Triangle Park, NC
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6163414
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Vol. 67:1
- Country of Publication:
- United States
- Language:
- English
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