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Title: Restriction of enhanced (2-/sup 14/C)deoxyglucose utilization to rhinencephalic structures in immature amygdala-kindled rats

Abstract

Sixteen-day-old albino rat pups were kindled to varying degrees of seizure severity with amygdala stimulations spaced 15 to 20 min apart. Subsequently, each rat pup was injected (ip) with 10 microCi of (2-/sup 14/C)-deoxyglucose, and received several additional kindled seizures at regular intervals throughout the following 80 min, at which time it was killed and processed for deoxyglucose autoradiography. Increased seizure severity was associated with correspondingly increased deoxyglucose utilization in many rhinencephalic limbic structures. However, unlike adults, rat pups did not show discernibly increased neocortical, thalamic, or substantia nigra utilization. We postulate that the apparent confinement of seizure activity to limbic structures in pups is related to their relative lack of postictal seizure refractoriness, as well as to other indices of increased seizure susceptibility in immature animals.

Authors:
; ;
Publication Date:
Research Org.:
Univ. of California, Los Angeles (USA)
OSTI Identifier:
6154449
Resource Type:
Journal Article
Journal Name:
Exp. Neurol.; (United States)
Additional Journal Information:
Journal Volume: 104:1
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BRAIN; PATHOLOGICAL CHANGES; GLUCOSE; METABOLISM; AUTORADIOGRAPHY; CARBON 14 COMPOUNDS; NEONATES; RATS; ALDEHYDES; ANIMALS; BODY; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM; HEXOSES; LABELLED COMPOUNDS; MAMMALS; MONOSACCHARIDES; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; RODENTS; SACCHARIDES; VERTEBRATES; 550501* - Metabolism- Tracer Techniques

Citation Formats

Ackermann, R F, Moshe, S L, and Albala, B J. Restriction of enhanced (2-/sup 14/C)deoxyglucose utilization to rhinencephalic structures in immature amygdala-kindled rats. United States: N. p., 1989. Web. doi:10.1016/0014-4886(89)90011-3.
Ackermann, R F, Moshe, S L, & Albala, B J. Restriction of enhanced (2-/sup 14/C)deoxyglucose utilization to rhinencephalic structures in immature amygdala-kindled rats. United States. https://doi.org/10.1016/0014-4886(89)90011-3
Ackermann, R F, Moshe, S L, and Albala, B J. 1989. "Restriction of enhanced (2-/sup 14/C)deoxyglucose utilization to rhinencephalic structures in immature amygdala-kindled rats". United States. https://doi.org/10.1016/0014-4886(89)90011-3.
@article{osti_6154449,
title = {Restriction of enhanced (2-/sup 14/C)deoxyglucose utilization to rhinencephalic structures in immature amygdala-kindled rats},
author = {Ackermann, R F and Moshe, S L and Albala, B J},
abstractNote = {Sixteen-day-old albino rat pups were kindled to varying degrees of seizure severity with amygdala stimulations spaced 15 to 20 min apart. Subsequently, each rat pup was injected (ip) with 10 microCi of (2-/sup 14/C)-deoxyglucose, and received several additional kindled seizures at regular intervals throughout the following 80 min, at which time it was killed and processed for deoxyglucose autoradiography. Increased seizure severity was associated with correspondingly increased deoxyglucose utilization in many rhinencephalic limbic structures. However, unlike adults, rat pups did not show discernibly increased neocortical, thalamic, or substantia nigra utilization. We postulate that the apparent confinement of seizure activity to limbic structures in pups is related to their relative lack of postictal seizure refractoriness, as well as to other indices of increased seizure susceptibility in immature animals.},
doi = {10.1016/0014-4886(89)90011-3},
url = {https://www.osti.gov/biblio/6154449}, journal = {Exp. Neurol.; (United States)},
number = ,
volume = 104:1,
place = {United States},
year = {Sat Apr 01 00:00:00 EST 1989},
month = {Sat Apr 01 00:00:00 EST 1989}
}