Lower efficiency of DTPA in reducing cadmium retention in suckling rats
The influence of age on the effectiveness of chelation therapy in enhancing cadmium elimination was studied in 1-, 2-, 8-, and 26-week-old rats. /sup 115m/Cd was administered intraperitoneally, followed immediately and after 24 hr by an intraperitoneal injection of trisodium calcium diethylenetriaminepentaacetate (DTPA) (600 ..mu..mole/kg body wt). The whole body retention determined on the second, fourth, and sixth days of the experiment showed that DTPA greatly decreased cadmium retention in all age groups being about four times more effective in older than younger animals. Determination of /sup 115m/Cd retention in the gut and organs also revealed that effectiveness of DTPA was lowest for the youngest age group and increased with increasing age. This effect of DTPA was more pronounced in the liver than in the kidney and brain in all age groups. These results indicate that age greatly influences chelation of cadmium and that age might be an important factor in chelation therapy in general.
- Research Organization:
- Inst. for Medical Research and Occupational Health, Zagreb, Yugoslavia
- OSTI ID:
- 6151703
- Journal Information:
- Environ. Res.; (United States), Vol. 35:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM
EXCRETION
RETENTION
DTPA
EFFICIENCY
AGE DEPENDENCE
BRAIN
CADMIUM 115
DECONTAMINATION
EVALUATION
EXPERIMENTAL DATA
ISOMERIC NUCLEI
KIDNEYS
LIVER
RATS
THERAPY
TISSUE DISTRIBUTION
TRACER TECHNIQUES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CADMIUM ISOTOPES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
CLEANING
CLEARANCE
DATA
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
NERVOUS SYSTEM
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)