Changes in lymphocyte and macrophage subsets due to morphine and ethanol treatment during a retrovirus infection causing murine AIDS
The number of lymphocytes of various subsets were not significantly changed by the ethanol exposure except those showing activation markers which were reduced. The percentage of peripheral blood cells showing markers for macrophage functions and their activation were significantly reduced after binge use of ethanol. Ethanol retarded suppression of cells by retroviral infection. However by 25 weeks of infection there was a 8.6% survival in the ethanol fed mice infected with retrovirus which was much less than virally infected controls. Morphine treatment also increased the percentage of cells with markers for macrophages and activated macrophages in virally infected mice, while suppressing them in uninfected mice. The second and third morphine injection series suppressed lymphocyte T-helper and T-suppressor cells, but not total T cells. However, suppression by morphine was significantly less during retroviral disease than suppression caused by the virus only. At 25 weeks of infection 44.8% of morphine treated, infected mice survived.
- Research Organization:
- Univ. of Arizona, Tucson (USA)
- OSTI ID:
- 6148099
- Journal Information:
- Life Sci.; (United States), Vol. 43:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ETHANOL
BIOLOGICAL EFFECTS
LYMPHOCYTES
IMMUNOSUPPRESSION
MACROPHAGES
MORPHINE
AIDS
BIOLOGICAL MARKERS
BIOLOGICAL MODELS
MICE
ALCOHOLS
ALKALOIDS
ANALGESICS
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CONNECTIVE TISSUE CELLS
DISEASES
DRUGS
HEMIC DISEASES
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
LEUKOCYTES
MAMMALS
MATERIALS
NARCOTICS
OPIUM
ORGANIC COMPOUNDS
PHAGOCYTES
RODENTS
SOMATIC CELLS
VERTEBRATES
VIRAL DISEASES
560300* - Chemicals Metabolism & Toxicology