Radiobiological speculations on therapeutic total body irradiation

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Critical Reviews in Oncology/Hematology; (USA)

DOI:https://doi.org/10.1016/1040-8428(90)90032-N· OSTI ID:6145871

Vriesendorp, H M ^[1]

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1. Johns Hopkins Hospital, Baltimore, MD (USA)

Unexpected total body irradiation (TBI) of human beings, involved in nuclear warfare or in accidents in nuclear reactors can be lethal. In the 1950s, bone marrow transplantation was discovered as a potentially life saving procedure after TBI in the dose range of 5.0 to 12.0 Gy. Since that time, deliberate or therapeutic TBI has been used to condition patients with a lethal bone marrow disorder for bone marrow replacement. The therapeutic ratio of TBI followed by bone marrow transplantation is small. Many potentially lethal complications can occur, such as acute TBI side effects, late TBI side effects or immunological complications of bone marrow transplantation such as graft versus host disease or graft rejection. The benefits of TBI and bone marrow transplantation are that they offer a chance for cure of previously lethal bone marrow disorders. The optimal parameters for TBI remain to be defined. The review discusses the current clinical and experimental animal data, as they relate to the future definition of less toxic TBI procedures with a better therapeutic ratio. Different TBI procedures are required for patients with malignant vs. non-malignant disorders or for patients with histoincompatible vs. histocompatible bone marrow donors.77 references.

• OSTI ID: 6145871
• Journal Information: Critical Reviews in Oncology/Hematology; (USA), Vol. 10:3; ISSN 1040-8428
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW
TRANSPLANTS
RADIOTHERAPY
WHOLE-BODY IRRADIATION
SKELETAL DISEASES
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
GRAFT-HOST REACTION
PATIENTS
RADIATION ACCIDENTS
REVIEWS
SIDE EFFECTS
ACCIDENTS
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BODY
DISEASES
DOCUMENT TYPES
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IRRADIATION
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
TISSUES
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man