Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation

Journal Article · Fri Dec 05 00:00:00 EST 1980 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.7003711· OSTI ID:6141704

Slavin, S; Yatziv, S

Enzyme deficiency was corrected in mice after allogeneic bone marrow transplantation with occurrence of graft versus host disease. Beta-Glucuronidase-deficient C3H/HeJ mice were treated with total lymphoid irradiation. Normal bone marrow cells (30 x 10(6)) from BALB/o to C3H/HeJ chimeras (> 90 percent circulating donor-type cells) without graft versus host disease. Beta-Glucuronidase activity increases to normal levels in all chimeras as measured in the liver and in the plasma. Activity was maintained throughout an observation period of 7 months.

• OSTI ID: 6141704
• Journal Information: Science (Washington, D.C.); (United States), Vol. 210:4474
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW
TRANSPLANTS
GLUCURONIDASE
ENZYME ACTIVITY
GRAFT-HOST REACTION
IRRADIATION
LYMPHATIC SYSTEM
MICE
RADIATION CHIMERAS
ANIMAL TISSUES
ANIMALS
BODY
CHIMERAS
ENZYMES
GLYCOSYL HYDROLASES
HEMATOPOIETIC SYSTEM
HYDROLASES
MAMMALS
MOSAICISM
O-GLYCOSYL HYDROLASES
ORGANS
RODENTS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals