Radioactive oxygen-15 in the study of cerebral blood flow, blood volume, and oxygen metabolism
The short half-life of /sup 15/O led early observers to believe that it was unsuitable for use as a biological tracer. However, initial studies with this nuclide demonstrated its potential usefulness for in vivo, regional physiologic measurements. Subsequently, techniques were developed to measure cerebral blood flow (CBF), blood volume, and oxygen metabolism using intracarotid injection of /sup 15/O-labeled radiopharmaceuticals and highly collimated scintillation probes to record the time course of radioactivity in the brain. The development of positron emission tomography (PET) made possible the in vivo, noninvasive measurement of the absolute concentration of positron-emitting nuclides. A variety of tracer kinetic models were formulated to obtain physiologic measurements from tomographic images of the distribution of 15O-labeled radiopharmaceuticals in the brain. Regional cerebral oxygen metabolism is measured using scan data obtained following the inhalation of /sup 15/O-labeled oxygen. The tracer kinetic models used to measure rCBV, blood flow, and oxygen metabolism will be described and their relative advantages and limitations discussed. Several examples of the use of /sup 15/O tracer methods will be reviewed to demonstrate their widespread applicability to the study of cerebral physiology and pathophysiology. 110 references.
- Research Organization:
- Washington Univ. School of Medicine, St Louis, MO
- OSTI ID:
- 6137557
- Journal Information:
- Semin. Nucl. Med.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD FLOW
DYNAMIC FUNCTION STUDIES
BRAIN
POSITRON COMPUTED TOMOGRAPHY
CARBON MONOXIDE
HALF-LIFE
METABOLISM
OXYGEN 15
VOLUME
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON COMPOUNDS
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
RADIOISOTOPES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics