Lysozyme levels in rabbit lung after inhalation of nickel, cadmium, cobalt, and copper chlorides

Lundborg, M; Camner, P

doi:10.1016/0013-9351(84)90102-6

Title: Lysozyme levels in rabbit lung after inhalation of nickel, cadmium, cobalt, and copper chlorides

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Abstract

Groups of rabbits were exposed to chlorides of nickel, cadmium, copper, and cobalt at concentrations ranging from 0.2 to 0.6 mg/m/sup 3/ (as metal) for 4 to 6 weeks (5 days/weeks, 6 hr/day). Activity of lysozyme (muramidase) in lavage fluid, in alveolar macrophages, and in culture medium from macrophages incubated at 37/sup 0/C for 1 and 20 hr was estimated using the lyso-plate technique, agar plates with heat-killed Micrococcus lysodeikticus. In the nickel-exposed rabbits lysozyme activity in the mucous membrane from the left main bronchus was also estimated. Following nickel exposure the lysozyme level was significantly decreased in lavage fluid, macrophages, and in culture medium from incubated macrophages but remained unchanged in the mucous membrane. After exposure to cadmium, copper, and cobalt, lysozyme levels increased or were unchanged.

Authors:: Lundborg, M; Camner, P

Publication Date:: Wed Aug 01 00:00:00 EDT 1984

Research Org.:: Karolinska Inst., Stockholm, Sweden

OSTI Identifier:: 6133970

Resource Type:: Journal Article

Journal Name:: Environ. Res.; (United States)

Additional Journal Information:: Journal Volume: 34:2

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM CHLORIDES; TOXICITY; COBALT CHLORIDES; COPPER CHLORIDES; LYSOZYME; ENZYME ACTIVITY; NICKEL CHLORIDES; BODY FLUIDS; BRONCHI; EXPERIMENTAL DATA; INHALATION; LUNGS; MACROPHAGES; MUCOUS MEMBRANES; RABBITS; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BODY; CADMIUM COMPOUNDS; CADMIUM HALIDES; CHLORIDES; CHLORINE COMPOUNDS; COBALT COMPOUNDS; CONNECTIVE TISSUE CELLS; COPPER COMPOUNDS; COPPER HALIDES; DATA; ENZYMES; GLYCOSYL HYDROLASES; HALIDES; HALOGEN COMPOUNDS; HYDROLASES; INFORMATION; INTAKE; MAMMALS; MATERIALS; MEMBRANES; NICKEL COMPOUNDS; NUMERICAL DATA; O-GLYCOSYL HYDROLASES; ORGANS; PHAGOCYTES; RESPIRATORY SYSTEM; SOMATIC CELLS; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

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                    Lundborg, M, and Camner, P. Lysozyme levels in rabbit lung after inhalation of nickel, cadmium, cobalt, and copper chlorides.  United States: N. p., 1984. 
        Web.  doi:10.1016/0013-9351(84)90102-6.

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                    Lundborg, M, & Camner, P. Lysozyme levels in rabbit lung after inhalation of nickel, cadmium, cobalt, and copper chlorides.  United States.  https://doi.org/10.1016/0013-9351(84)90102-6

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                    Lundborg, M, and Camner, P. 1984.  
        "Lysozyme levels in rabbit lung after inhalation of nickel, cadmium, cobalt, and copper chlorides".  United States.  https://doi.org/10.1016/0013-9351(84)90102-6.

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@article{osti_6133970,

  title        = {Lysozyme levels in rabbit lung after inhalation of nickel, cadmium, cobalt, and copper chlorides},

  author       = {Lundborg, M and Camner, P},

  abstractNote = {Groups of rabbits were exposed to chlorides of nickel, cadmium, copper, and cobalt at concentrations ranging from 0.2 to 0.6 mg/m/sup 3/ (as metal) for 4 to 6 weeks (5 days/weeks, 6 hr/day). Activity of lysozyme (muramidase) in lavage fluid, in alveolar macrophages, and in culture medium from macrophages incubated at 37/sup 0/C for 1 and 20 hr was estimated using the lyso-plate technique, agar plates with heat-killed Micrococcus lysodeikticus. In the nickel-exposed rabbits lysozyme activity in the mucous membrane from the left main bronchus was also estimated. Following nickel exposure the lysozyme level was significantly decreased in lavage fluid, macrophages, and in culture medium from incubated macrophages but remained unchanged in the mucous membrane. After exposure to cadmium, copper, and cobalt, lysozyme levels increased or were unchanged.},

  doi          = {10.1016/0013-9351(84)90102-6},

  url          = {https://www.osti.gov/biblio/6133970},
  journal      = {Environ. Res.; (United States)},
number       = ,

  volume       = 34:2,

  place        = {United States},

  year         = {Wed Aug 01 00:00:00 EDT 1984},

  month        = {Wed Aug 01 00:00:00 EDT 1984}

}

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