A new route towards the synthesis of multi-tritiomethyl iodide

Conference · Wed Jun 01 00:00:00 EDT 1988

OSTI ID:6107037

Saljoughian, M.; Morimoto, H.; Rapoport, H.

A new procedure for the synthesis of multi-tritiated methyl iodide is reported. In this procedure trichloromethylphenyl sulfide was prepared and the trichloromethyl group was hydrogenolysed in the presence of 10% Pd/C and an organic base with deuterium gas to give the corresponding deuterated sulfide as the precursor. Upon heating a mixture of the latter with excess of benzyl iodide in a special apparatus benzylphenyl sulfide remained as a solid by-product and liberated deuteriated methyl iodide was directly reacted with several simple amines to be N-deuteriomethylated. This new synthetic method can be extended to the tritiomethyl labeling of a variety of organic compounds having a methyl group attached to a heteroatom such as N, O and S. 12 refs.

• Research Organization: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 6107037
• Report Number(s): LBL-25587; CONF-880787-5; ON: DE89013690
• Resource Relation: Conference: 3. international symposium on the synthesis and applications of isotopically labeled compounds, Innsbruck, Austria, 17 Jul 1988; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
METHYL IODIDE
LABELLING
ANISOLE
CHEMICAL REACTIONS
CHLORINATION
SULFIDES
SYNTHESIS
TRITIUM
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHALCOGENIDES
ETHERS
HALOGENATED ALIPHATIC HYDROCARBONS
HALOGENATION
HYDROGEN ISOTOPES
IODINATED ALIPHATIC HYDROCARBONS
ISOTOPES
LIGHT NUCLEI
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
RADIOISOTOPES
SULFUR COMPOUNDS
YEARS LIVING RADIOISOTOPES
400202* - Isotope Effects
Isotope Exchange
& Isotope Separation