Influence of cadmium on isolated peritoneal macrophage populations: cadmium inhibits Fc receptor internalization

Thesis/Dissertation · Tue Jan 01 00:00:00 EST 1985

OSTI ID:6105368

Cook, G B

In vitro experiments were performed to examine the effect of cadmium on adherent phagocytic cell populations. The authors were able to demonstrate, in vitro, a phagocytic defect that was originally observed in an in vivo system. Using in vitro methodologies, cadmium was found to inhibit opsonin-dependent but not opsonin-independent phagocytosis in two different populations of macrophages. The receptors through which the opsonized /sup 51/Cr-ElgG were internalized were characterized as Fc receptors. They were able to demonstrate that cadmium could reversibly inhibit internalization of Fc receptors. This mechanism, rather than an alteration of the receptors' binding capabilities, was responsible for the observed inhibition of Fc mediated (opsonin-dependent) phagocytosis in both populations of macrophages tested. The defect was not specific for cadmium per se. Zinc treatment caused a similar inhibition of Fc receptor mediated phagocytosis.

• Research Organization: California Univ., Los Angeles (USA)
• OSTI ID: 6105368
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
CADMIUM COMPOUNDS
BIOLOGICAL EFFECTS
CHROMIUM 51
TRACER TECHNIQUES
PHAGOCYTOSIS
INHIBITION
MACROPHAGES
PERITONEUM
RECEPTORS
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MEMBRANE PROTEINS
MEMBRANES
NUCLEI
ORGANIC COMPOUNDS
PHAGOCYTES
PROTEINS
RADIOISOTOPES
SEROUS MEMBRANES
SOMATIC CELLS
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics