Crossed cerebellar and uncrossed basal ganglia and thalamic diaschisis in Alzheimer's disease

Journal Article · Sat Apr 01 00:00:00 EST 1989 · Neurology; (United States)

OSTI ID:6100242

Akiyama, H; Harrop, R; McGeer, P L; Peppard, R; McGeer, E G

We detected crossed cerebellar as well as uncrossed basal ganglia and thalamic diaschisis in Alzheimer's disease by positron emission tomography (PET) using /sup 18/F-fluorodeoxyglucose. We studied a series of 26 consecutive, clinically diagnosed Alzheimer cases, including 6 proven by later autopsy, and compared them with 9 age-matched controls. We calculated asymmetry indices (AIs) of cerebral metabolic rate for matched left-right regions of interest (ROIs) and determined the extent of diaschisis by correlative analyses. For the Alzheimer group, we found cerebellar AIs correlated negatively, and thalamic AIs positively, with those of the cerebral hemisphere and frontal, temporal, parietal, and angular cortices, while basal ganglia AIs correlated positively with frontal cortical AIs. The only significant correlation of AIs for normal subjects was between the thalamus and cerebral hemisphere. These data indicate that PET is a sensitive technique for detecting diaschisis.

• Research Organization: Univ. of British Columbia, Vancouver (Canada)
• OSTI ID: 6100242
• Journal Information: Neurology; (United States), Vol. 39:4
• Country of Publication: United States
• Language: English

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