Activity of the human carcinogen MeCCNU in the mouse bone marrow micronucleus assay

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Environmental and Molecular Mutagenesis; (United States)

DOI:https://doi.org/10.1002/em.2850170303· OSTI ID:6097878

Tinwell, H; Ashby, J ^[1]

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1. ICI Central Toxicology Lab, Cheshire (England)

The nitrosourea mustard MeCCNU is the most recent organic chemical to be classified as a human carcinogen by IARC. MeCCNU gave a strong positive response when tested in the mouse bone marrow micronucleus assay. Activity was evident using either ip injection or oral gavage of the test chemical. These results further support the correlation between human carcinogens and their genotoxicity.

• OSTI ID: 6097878
• Journal Information: Environmental and Molecular Mutagenesis; (United States), Vol. 17:3; ISSN 0893-6692
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW CELLS
CARCINOGENESIS
NITROSOUREAS
BIOLOGICAL EFFECTS
MAN
MICE
ANIMAL CELLS
ANIMALS
CONNECTIVE TISSUE CELLS
MAMMALS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PRIMATES
RODENTS
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology