Accelerated heavy particles and the lens. III. Cataract enhancement by dose fractionation

Journal Article · Sat Apr 01 00:00:00 EST 1989 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3577425· OSTI ID:6097023

Worgul, B V; Merriam, Jr, G R; Medvedovsky, C; Brenner, D J

For a number of biological end points it has been shown that, in contrast to low linear energy transfer (LET) radiation, dose fractionation of high-LET radiation does not result in a reduction in overall effectiveness. Studies were conducted to determine the effect of fractionating the exposures to heavy ion doses on the development of cataracts. Rat eyes were exposed to single doses of 1, 5, and 25 cGy of 570 MeV/amu40Ar ions and to 2, 4, and 10 Gy of 250 kVp X rays. These were compared to unirradiated controls and eyes which were exposed to the same total dose delivered in four fractions over 12 h. While in all cases fractionation of the exposure to X rays produced significant reduction in cataractogenic potential, fractionating doses of 40Ar ions caused a dose- and stage-dependent enhancement in the development of cataracts.

• Research Organization: Columbia Univ., New York, NY (USA)
• OSTI ID: 6097023
• Journal Information: Radiat. Res.; (United States), Vol. 118:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CATARACTS
RADIOINDUCTION
CRYSTALLINE LENS
RADIATION DOSES
X RADIATION
RBE
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
LET
RATS
ANIMALS
BODY
BODY AREAS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
ENERGY TRANSFER
EYES
FACE
HEAD
IONIZING RADIATIONS
IRRADIATION
MAMMALS
ORGANS
RADIATIONS
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals