skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Deposition, retention, and biological fate of inhaled benzo(a)pyrene adsorbed onto ultrafine particles and as a pure aerosol

Abstract

The effect of ultrafine, airborne, carrier particles on the deposition, retention, and biological fate of inhaled polycyclic aromatic hydrocarbons (PAHs) was studied. Using a radiolabeled model PAH, (/sup 3/H)benzo(a)pyrene ((/sup 3/H)BaP), Fischer-344 rats were exposed by nose-only inhalation (30 min) to this compound, as a coating (15% by mass) on insoluble /sup 67/Ga/sub 2/O/sub 3/ particles or as a pure aerosol. These aerosols were produced by vapor condensation methods in a dynamic aerosol generation system. The concentrations of (/sup 3/H)BaP in the coated and homogeneous aerosols were 0.6 and 1.0 ..mu..g/liter of air, respectively, while the mass median diameter of both these aerosols was approximately 0.1 ..mu..m. Pulmonary retention of /sup 3/H radioactivity was longer in animals exposed to the (/sup 3/H)BaP coated on the /sup 67/Ga/sub 2/O/sub 3/ particles. The time required to clear 90% of the initial lung burden of /sup 67/Ga/sub 2/O/sub 3/-associated /sup 3/H radioactivity detected 30 min postexposure was approximately 1 day as compared to 4 hr for animals ex Tracheal clearance of 90% of the /sup 67/Ga/sub 2/O/sub 3/-associated /sup 3/H radioactivity required 1 day, while only 1.5 hr were required to clear the same percentage of /sup 3/H radioactivity from the tracheas ofmore » rats exposed to the pure (/sup 3/H)BaP aerosol. The rates of clearance of this /sup 3/H material to other tissues suggested that a substantial amount of the (/sup 3/H)BaP coated on /sup 67/Ga/sub 2/O/sub 3/ was cleared from lungs by mucociliary clearance and subsequent ingestion, whereas the majority of the pure (/sup 3/H)BaP aerosol was cleared by direct absorption into blood. In both cases, the ultimate fate of the majority of the (/sup 3/H)BaP and its metabolites was excretion in feces.« less

Authors:
; ;
Publication Date:
Research Org.:
Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM
OSTI Identifier:
6094594
DOE Contract Number:  
AC04-76EV01013
Resource Type:
Journal Article
Journal Name:
Toxicol. Appl. Pharmacol.; (United States)
Additional Journal Information:
Journal Volume: 65
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; BENZOPYRENE; LUNG CLEARANCE; RETENTION; AEROSOLS; DEPOSITION; EXCRETION; EXPERIMENTAL DATA; GALLIUM 67; GASTROINTESTINAL TRACT; INHALATION; PARTICULATES; RATS; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMALS; AROMATICS; BETA DECAY RADIOISOTOPES; CLEARANCE; COLLOIDS; CONDENSED AROMATICS; DATA; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISPERSIONS; ELECTRON CAPTURE RADIOISOTOPES; GALLIUM ISOTOPES; HYDROCARBONS; INFORMATION; INTAKE; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PARTICLES; RADIOISOTOPES; RODENTS; SOLS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550501 - Metabolism- Tracer Techniques

Citation Formats

Sun, J D, Wolff, R K, and Kanapilly, G M. Deposition, retention, and biological fate of inhaled benzo(a)pyrene adsorbed onto ultrafine particles and as a pure aerosol. United States: N. p., 1982. Web. doi:10.1016/0041-008X(82)90005-9.
Sun, J D, Wolff, R K, & Kanapilly, G M. Deposition, retention, and biological fate of inhaled benzo(a)pyrene adsorbed onto ultrafine particles and as a pure aerosol. United States. https://doi.org/10.1016/0041-008X(82)90005-9
Sun, J D, Wolff, R K, and Kanapilly, G M. 1982. "Deposition, retention, and biological fate of inhaled benzo(a)pyrene adsorbed onto ultrafine particles and as a pure aerosol". United States. https://doi.org/10.1016/0041-008X(82)90005-9.
@article{osti_6094594,
title = {Deposition, retention, and biological fate of inhaled benzo(a)pyrene adsorbed onto ultrafine particles and as a pure aerosol},
author = {Sun, J D and Wolff, R K and Kanapilly, G M},
abstractNote = {The effect of ultrafine, airborne, carrier particles on the deposition, retention, and biological fate of inhaled polycyclic aromatic hydrocarbons (PAHs) was studied. Using a radiolabeled model PAH, (/sup 3/H)benzo(a)pyrene ((/sup 3/H)BaP), Fischer-344 rats were exposed by nose-only inhalation (30 min) to this compound, as a coating (15% by mass) on insoluble /sup 67/Ga/sub 2/O/sub 3/ particles or as a pure aerosol. These aerosols were produced by vapor condensation methods in a dynamic aerosol generation system. The concentrations of (/sup 3/H)BaP in the coated and homogeneous aerosols were 0.6 and 1.0 ..mu..g/liter of air, respectively, while the mass median diameter of both these aerosols was approximately 0.1 ..mu..m. Pulmonary retention of /sup 3/H radioactivity was longer in animals exposed to the (/sup 3/H)BaP coated on the /sup 67/Ga/sub 2/O/sub 3/ particles. The time required to clear 90% of the initial lung burden of /sup 67/Ga/sub 2/O/sub 3/-associated /sup 3/H radioactivity detected 30 min postexposure was approximately 1 day as compared to 4 hr for animals ex Tracheal clearance of 90% of the /sup 67/Ga/sub 2/O/sub 3/-associated /sup 3/H radioactivity required 1 day, while only 1.5 hr were required to clear the same percentage of /sup 3/H radioactivity from the tracheas of rats exposed to the pure (/sup 3/H)BaP aerosol. The rates of clearance of this /sup 3/H material to other tissues suggested that a substantial amount of the (/sup 3/H)BaP coated on /sup 67/Ga/sub 2/O/sub 3/ was cleared from lungs by mucociliary clearance and subsequent ingestion, whereas the majority of the pure (/sup 3/H)BaP aerosol was cleared by direct absorption into blood. In both cases, the ultimate fate of the majority of the (/sup 3/H)BaP and its metabolites was excretion in feces.},
doi = {10.1016/0041-008X(82)90005-9},
url = {https://www.osti.gov/biblio/6094594}, journal = {Toxicol. Appl. Pharmacol.; (United States)},
number = ,
volume = 65,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1982},
month = {Fri Jan 01 00:00:00 EST 1982}
}