Time- and loading-dependence in the McKone model for dermal uptake of organic chemicals from a soil matrix

Journal Article · Sun Sep 01 00:00:00 EDT 1991 · Risk Analysis; (United States)

DOI:https://doi.org/10.1111/j.1539-6924.1991.tb00634.x· OSTI ID:6093664

Burmaster, D E; Maxwell, N I ^[1]

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1. Alceon Corporation, Cambridge, MA (United States)

McKone has recently proposed an innovative two-layer model for dermal uptake of organic chemicals from a soil matrix that explicitly includes variables for properties of the chemical, the soil, the skin, and the exposure. In this note, the authors investigate the joint time- and loading-dependencies implicit in the model by using MATHEMATICA to find and plot a closed-form function for the uptake fraction for six aromatic hydrocarbons.

• OSTI ID: 6093664
• Journal Information: Risk Analysis; (United States), Vol. 11:3; ISSN 0272-4332
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
POLYCYCLIC AROMATIC HYDROCARBONS
SKIN ABSORPTION
COMPUTERIZED SIMULATION
MATHEMATICAL MODELS
SOILS
TIME DEPENDENCE
ABSORPTION
AROMATICS
HYDROCARBONS
ORGANIC COMPOUNDS
SIMULATION
UPTAKE
560300* - Chemicals Metabolism & Toxicology