Dose-effect and dose-response relationships of blood lead to erythrocytic protoporphyrin in young children
Dose-effect and dose-response relationships were analyzed for blood lead concentration (PbB) vs blood protoporphyrin concentration using multiple data points from 165 children, ages 3-36 months. Protoporphyrin concentrations were measured using a front-face flurometer designed to measure zinc protoporphyrin (ZPP) and an extraction method designed to measure total protoporphyrin as the free base (FEP). Estimations were made of the thresholds for PbB effects on FEP and ZPP, as well as the slopes of the PbB-FEP and PbB-ZPP interactions. There was essentially no difference in thresholds estimated using ZPP vs FEP as the effect parameter. There was no apparent effect of age on threshold. However, the slope for PbB vs ZPP was less steep than the slope for PbB vs FEP. Moreover, the average ratio FEP:ZPP was markedly elevated at 3 months (1.84:1) and decreased slowly, attaining unity at 33 months. The possible reasons for this discrepancy are discussed, as well as the implications for interpretation of lead screening program data.
- Research Organization:
- Univ. of Cincinnati Medical Center, OH
- OSTI ID:
- 6079930
- Journal Information:
- Environ. Res.; (United States), Vol. 38:1; Conference: 2. international conference on prospective studies of lead, Cincinnati, OH, USA, 9-11 Apr 1984
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHILDREN
SCREENING
LEAD
BLOOD CHEMISTRY
HEALTH HAZARDS
PROTOPORPHYRINS
BIOCHEMICAL REACTION KINETICS
BLOOD
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
AGE GROUPS
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBOXYLIC ACIDS
DATA
ELEMENTS
HAZARDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INFORMATION
KINETICS
MATERIALS
METALS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
REACTION KINETICS
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)