Technetium-99m pyrophosphate uptake in experimental viral perimyocarditis: sequential study of myocardial uptake and pathologic correlates

Journal Article · Tue Apr 01 00:00:00 EST 1980 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.61.4.802· OSTI ID:6079894

Matsumori, A; Kadota, K; Kawai, C

The myocardial uptake of technetium-99m pyrophosphate (/sup 99m/Tc-PYP) in perimyocarditis induced by coxsackievirus B3 in BALB/c mice was studied. /sup 99m/Tc-PYP uptake ratio, measured by the ratio of counts/min per gram for the heart to counts/min per gram for the skull, began to increase 5 days after virus inoculation when myocardial necroosis was evident. On the seventh day after the inoculation, /sup 99m/Tc-PYP ratio reached a maximum. Histologically, fine, dystrophic calcification appeared in the necrotic fibers. /sup 99m/Tc-PYP uptake was in proportion to the extent of the myocardial lesions. Thereafter, cellular infiltrations increased with time and were most severe on the fourteenth day, but /sup 99m/Tc-PYP ratio had begun to fade. On the twenty-eighth day, perimyocardial fibrosis increased and calcification was still present, but /sup 99m/Tc-PYP ratio had decreased. Myocardial uptake with severe pathologic lesions was visualized on a whole-body image on the seventh day after inoculation with the virus. The findings may provide a basis upon which /sup 99m/Tc-PYP imaging may be applied to viral perimyocarditis in humans.

• Research Organization: Kyoto Univ. (Japan)
• OSTI ID: 6079894
• Journal Information: Circulation; (United States), Vol. 61:4
• Country of Publication: United States
• Language: English

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