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Title: Effect of beta blockade on single photon emission computed tomographic (SPECT) thallium-201 images in patients with coronary disease

Abstract

We evaluated the effect of beta blockers on thallium-201 (Tl-201) single photon emission computed tomographic (SPECT) imaging in 12 patients with coronary disease using an automated computer algorithm. Maximal exercise heart rate and blood pressure were reduced and exercise time was increased with beta blockers. Estimated stress defect size decreased from 47 +/- 36.3 gm during placebo treatment to 32 +/- 27.1 gm during beta blocker therapy (-32%; p less than 0.01). The placebo treatment redistribution defect was estimated to be 28 +/- 29.8 gm. It fell to 15 +/- 23.3 gm with beta blockade (-46%; p less than 0.005). All patients had a stress Tl-201 defect during placebo treatment and eight had redistribution defects consistent with residual scar. During beta blocker therapy, 2 of 12 patients had normal stress-redistribution studies and only five patients had redistribution defects. Beta blockade can reduce exercise and redistribution Tl-201 SPECT defect size significantly while simultaneously increasing exercise time and reducing angina. Beta blockers may unmask or may eliminate evidence of redistribution. Tl-201 SPECT imaging may be useful in defining the reduction in ischemia produced by cardiac drugs.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Harbor-UCLA Medical Center, Torrance (USA)
OSTI Identifier:
6073978
Resource Type:
Journal Article
Journal Name:
Am. Heart J.; (United States)
Additional Journal Information:
Journal Volume: 117:5
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARDIOVASCULAR DISEASES; DIAGNOSIS; HEART; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SYMPATHOLYTICS; BIOLOGICAL EFFECTS; ALGORITHMS; BLOOD PRESSURE; EXERCISE; PATIENTS; THALLIUM 201; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATHEMATICAL LOGIC; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Narahara, K A, Thompson, C J, Hazen, J F, Brizendine, M, and Mena, I. Effect of beta blockade on single photon emission computed tomographic (SPECT) thallium-201 images in patients with coronary disease. United States: N. p., 1989. Web. doi:10.1016/0002-8703(89)90858-2.
Narahara, K A, Thompson, C J, Hazen, J F, Brizendine, M, & Mena, I. Effect of beta blockade on single photon emission computed tomographic (SPECT) thallium-201 images in patients with coronary disease. United States. https://doi.org/10.1016/0002-8703(89)90858-2
Narahara, K A, Thompson, C J, Hazen, J F, Brizendine, M, and Mena, I. 1989. "Effect of beta blockade on single photon emission computed tomographic (SPECT) thallium-201 images in patients with coronary disease". United States. https://doi.org/10.1016/0002-8703(89)90858-2.
@article{osti_6073978,
title = {Effect of beta blockade on single photon emission computed tomographic (SPECT) thallium-201 images in patients with coronary disease},
author = {Narahara, K A and Thompson, C J and Hazen, J F and Brizendine, M and Mena, I},
abstractNote = {We evaluated the effect of beta blockers on thallium-201 (Tl-201) single photon emission computed tomographic (SPECT) imaging in 12 patients with coronary disease using an automated computer algorithm. Maximal exercise heart rate and blood pressure were reduced and exercise time was increased with beta blockers. Estimated stress defect size decreased from 47 +/- 36.3 gm during placebo treatment to 32 +/- 27.1 gm during beta blocker therapy (-32%; p less than 0.01). The placebo treatment redistribution defect was estimated to be 28 +/- 29.8 gm. It fell to 15 +/- 23.3 gm with beta blockade (-46%; p less than 0.005). All patients had a stress Tl-201 defect during placebo treatment and eight had redistribution defects consistent with residual scar. During beta blocker therapy, 2 of 12 patients had normal stress-redistribution studies and only five patients had redistribution defects. Beta blockade can reduce exercise and redistribution Tl-201 SPECT defect size significantly while simultaneously increasing exercise time and reducing angina. Beta blockers may unmask or may eliminate evidence of redistribution. Tl-201 SPECT imaging may be useful in defining the reduction in ischemia produced by cardiac drugs.},
doi = {10.1016/0002-8703(89)90858-2},
url = {https://www.osti.gov/biblio/6073978}, journal = {Am. Heart J.; (United States)},
number = ,
volume = 117:5,
place = {United States},
year = {Mon May 01 00:00:00 EDT 1989},
month = {Mon May 01 00:00:00 EDT 1989}
}