Noninvasive method to assess cor pulmonale in patients with chronic obstructive pulmonary disease
In our study of 15 patients with chronic obstructive pulmonary disease, we performed myocardial perfusion single-photon-emission computerized tomography (SPECT) with thallium-201 to quantitatively assess right ventricular hypertrophy. On the SPECT images, we determined the ratio of activity in the right-to-left ventricular wall as the thallium score. Right ventricular ejection fraction (RVEF) was measured by multigated equilibrium radionuclide ventriculography with krypton-81m. Both the thallium scores and RVEF values correlated well with pulmonary arterial pressure (r = 0.65 and r = -0.86, respectively) and permitted the structural and functional assessment of cor pulmonale. When the patients were classified according to the thallium scores and RVEF values, those who had both a high thallium score and reduced RVEF had a significantly high pulmonary arterial pressure and vice versa. The combined evaluation of the thallium score and RVEF enabled accurate noninvasive assessment of cor pulmonale.
- Research Organization:
- Kyoto Univ., Japan
- OSTI ID:
- 6073753
- Journal Information:
- Chest; (United States), Vol. 92:1
- Country of Publication:
- United States
- Language:
- English
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THALLIUM 201
BETA DECAY RADIOISOTOPES
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
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HEAVY NUCLEI
INTERMEDIATE MASS NUCLEI
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550601* - Medicine- Unsealed Radionuclides in Diagnostics