Tuberoinfundibular transport of intrahypothalamic-administered dopamine in normo- and hypertensive rats

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Clin. Exp. Hypertens., Part A; (United States)

OSTI ID:6073481

Sim, M K

The dopamine transport system in the tuberoinfundibular tract of the spontaneously hypertensive (SHR), Wistar Kyoto (WKY) and Sprague-Dawley (SD) rats was investigated. The results show that the rate of dopamine transport in this tract is strain-specific. SD rats transported twice as much dopamine (in 30 minutes) as WKY and SHR. The dopamine transport system in the SHR, being at par with that of the WKY, remained intact. These findings suggest that hypertension and the alleged reduced central dopaminergic activity in the SHR is not related to the transport of dopamine in the tuberoinfundibular tract.

• Research Organization: National Univ. of Singapore
• OSTI ID: 6073481
• Journal Information: Clin. Exp. Hypertens., Part A; (United States), Vol. 10:6
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
MEMBRANE TRANSPORT
HYPERTENSION
PATHOGENESIS
GENETIC VARIABILITY
HYPOTHALAMUS
PITUITARY GLAND
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL VARIABILITY
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
DISEASES
DRUGS
ENDOCRINE GLANDS
GLANDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RODENTS
SYMPATHOMIMETICS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
550901* - Pathology- Tracer Techniques