Dynamic positron tomographic imaging with nitrogen-13 glutamate in patients with coronary artery disease: Comparison with nitrogen-13 ammonia and fluorine-18 fluorodeoxyglucose imaging

Journal Article · Thu Nov 01 00:00:00 EST 1990 · Journal of the American College of Cardiology; (USA)

DOI:https://doi.org/10.1016/0735-1097(90)90548-4· OSTI ID:6071011

Krivokapich, J; Barrio, J R; Huang, S C; Schelbert, H R ^[1]

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1. Univ. of California, Los Angeles (USA)

This study was designed to test the usefulness of nitrogen-13 (N-13) glutamate imaging with positron emission tomography in defining myocardial ischemia in humans. Seventeen patients who had undergone coronary arteriography were studied with N-13 glutamate at peak supine exercise using a bicycle ergometer, as well as with the flow tracer N-13 ammonia at peak exercise during a second similar exercise test. Six of the patients also underwent imaging with N-13 glutamate at rest before exercise testing; in the remaining 11 patients imaging with fluorine-18 (F-18) fluorodeoxyglucose was performed to assess glucose metabolism after the second exercise test. Seven patients had classic metabolism-flow mismatches consistent with ischemia (that is, decreased N-13 ammonia uptake in a region with relatively increased F-18 fluorodeoxyglucose uptake). There was no evidence of increased N-13 glutamate uptake in the ischemic mismatched regions in any of these patients. In all 17 patients, the uptake of N-13 glutamate during exercise paralleled the uptake of N-13 ammonia during exercise, suggesting that N-13 glutamate behaves as a flow tracer rather than as a metabolic marker of ischemia in humans.

• OSTI ID: 6071011
• Journal Information: Journal of the American College of Cardiology; (USA), Vol. 16:5; ISSN 0735-1097
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ISCHEMIA
DIAGNOSIS
RADIOPHARMACEUTICALS
EFFICIENCY
COMPARATIVE EVALUATIONS
EXERCISE
MAN
MYOCARDIUM
NITROGEN 13
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
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CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEART
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
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TOMOGRAPHY
VASCULAR DISEASES
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