Radiation-induced leiomyosarcoma of the great vessels presenting as superior vena cava syndrome
A patient with a pleomorphic intravascular leiomyosarcoma of the great vessels of the neck and mediastinum presented clinically with a superior vena cava syndrome. A latent period of 29 years elapsed between receiving orthovoltage radiation to the neck and right side of chest to treat recurrent ganglioneuroblastoma, and the appearance of a leiomyosarcoma and subsequent recurrences. The patient underwent partial resection of the tumor, received adjunct chemotherapy, and was shown to be free of disease by clinical tests and by magnetic resonance imaging (MRI) 17 months after completion of chemotherapy. The criteria for the diagnosis of radiation-induced sarcomas are reviewed in relation to the present case. The critical role of magnetic resonance imaging in both the diagnosis and continued follow-up of the patient is described. This would appear to be the first reported case of radiation-induced intravascular leiomyosarcoma of the great vessels of the neck and mediastinum presenting as a superior vena cava syndrome.
- Research Organization:
- Allegheny General Hospital, Pittsburgh, PA
- OSTI ID:
- 6069156
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 60:6
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
MEDIASTINUM
SARCOMAS
NECK
RADIOTHERAPY
SIDE EFFECTS
DIAGNOSIS
RADIOINDUCTION
CHEMOTHERAPY
DELAYED RADIATION EFFECTS
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
PATIENTS
SURGERY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHEST
DIAGNOSTIC TECHNIQUES
DISEASES
MAGNETIC RESONANCE
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOLOGY
RESONANCE
THERAPY
560151* - Radiation Effects on Animals- Man
550600 - Medicine