skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Increased chromium and nickel content in lung tissue and bronchial carcinoma

Abstract

In 25 random autopsies, chromium (Cr) and nickel (Ni) in lung tissue and regional lymph nodes were analysed by means of flameless atomic absorption spectrometry (AAS). The subjects originate from Bochum in the Ruhr District, which is defined as a particular pollution area with locally high Cr and Ni emissions. The subjects examined from Bochum (BO) and vicinity have Cr and Ni concentrations about 5 and 6 times higher than those in a previous series form Muenster (MS) and vicinity (outside the particular pollution area), which is used for comparison purposes. BO and MS data showed an age-dependent increase of chromium and nickel in the lung, and in both data sets as well as in the combined, the Cr and Ni values showed extremely high correlations. The Cr and Ni concentrations (BO) in lung (3.47 +/- 2.53 micrograms Cr/g, 1.09 +/- 1.43 micrograms Ni/g dry weight) and lymph node tissue (6.30 +/- 3.72 micrograms Cr/g, 1.00 +/- 0.58 micrograms Ni/g dry weight) do not show any correlation. The BO data contained four cases of bronchial carcinoma (all male), three of which showed pulmonary Cr and Ni concentrations that lie clearly above the predicted level. One case of bronchial carcinoma hadmore » extremely high Cr and Ni values; an occupational exposure as dental laboratory technician is taken into consideration.« less

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Bundesanstalt fuer Arbeitsschutz, Dortmund, Germany, F.R.
OSTI Identifier:
6068368
Resource Type:
Journal Article
Journal Name:
Am. J. Ind. Med.; (United States)
Additional Journal Information:
Journal Volume: 11:6
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHROMIUM; BIOLOGICAL ACCUMULATION; HEALTH HAZARDS; NICKEL; ABSORPTION SPECTROSCOPY; AGE DEPENDENCE; AIR POLLUTION; AUTOPSY; CARCINOGENESIS; CORRELATIONS; DATA ANALYSIS; ENVIRONMENTAL EXPOSURE; FEDERAL REPUBLIC OF GERMANY; INDUSTRIAL WASTES; LUNGS; LYMPH NODES; OCCUPATIONAL EXPOSURE; STATISTICAL DATA; BODY; DATA; DIAGNOSTIC TECHNIQUES; ELEMENTS; EUROPE; HAZARDS; INFORMATION; LYMPHATIC SYSTEM; METALS; NUMERICAL DATA; ORGANS; PATHOGENESIS; POLLUTION; RESPIRATORY SYSTEM; SPECTROSCOPY; TRANSITION ELEMENTS; WASTES; WESTERN EUROPE; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Kollmeier, H, Seemann, J W, Mueller, K M.R., Rothe, G, Wittig, P, and Schejbal, V B. Increased chromium and nickel content in lung tissue and bronchial carcinoma. United States: N. p., 1987. Web. doi:10.1002/ajim.4700110607.
Kollmeier, H, Seemann, J W, Mueller, K M.R., Rothe, G, Wittig, P, & Schejbal, V B. Increased chromium and nickel content in lung tissue and bronchial carcinoma. United States. https://doi.org/10.1002/ajim.4700110607
Kollmeier, H, Seemann, J W, Mueller, K M.R., Rothe, G, Wittig, P, and Schejbal, V B. 1987. "Increased chromium and nickel content in lung tissue and bronchial carcinoma". United States. https://doi.org/10.1002/ajim.4700110607.
@article{osti_6068368,
title = {Increased chromium and nickel content in lung tissue and bronchial carcinoma},
author = {Kollmeier, H and Seemann, J W and Mueller, K M.R. and Rothe, G and Wittig, P and Schejbal, V B},
abstractNote = {In 25 random autopsies, chromium (Cr) and nickel (Ni) in lung tissue and regional lymph nodes were analysed by means of flameless atomic absorption spectrometry (AAS). The subjects originate from Bochum in the Ruhr District, which is defined as a particular pollution area with locally high Cr and Ni emissions. The subjects examined from Bochum (BO) and vicinity have Cr and Ni concentrations about 5 and 6 times higher than those in a previous series form Muenster (MS) and vicinity (outside the particular pollution area), which is used for comparison purposes. BO and MS data showed an age-dependent increase of chromium and nickel in the lung, and in both data sets as well as in the combined, the Cr and Ni values showed extremely high correlations. The Cr and Ni concentrations (BO) in lung (3.47 +/- 2.53 micrograms Cr/g, 1.09 +/- 1.43 micrograms Ni/g dry weight) and lymph node tissue (6.30 +/- 3.72 micrograms Cr/g, 1.00 +/- 0.58 micrograms Ni/g dry weight) do not show any correlation. The BO data contained four cases of bronchial carcinoma (all male), three of which showed pulmonary Cr and Ni concentrations that lie clearly above the predicted level. One case of bronchial carcinoma had extremely high Cr and Ni values; an occupational exposure as dental laboratory technician is taken into consideration.},
doi = {10.1002/ajim.4700110607},
url = {https://www.osti.gov/biblio/6068368}, journal = {Am. J. Ind. Med.; (United States)},
number = ,
volume = 11:6,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 1987},
month = {Thu Jan 01 00:00:00 EST 1987}
}