Variation in tumor response to fluosol-DA (20%)

Journal Article · Mon May 01 00:00:00 EDT 1989 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(89)90271-X· OSTI ID:6067940

Sasai, K; Ono, K; Nishidai, T; Tsutsui, K; Shibamoto, Y; Takahashi, M; Abe, M

The effects of Fluosol-DA 20% (FDA) and carbogen (95% O2/5% CO/sub 2/) on radiosensitivity of the three experimental tumors, SCC VII tumor, RIF-I tumor, and transplanted mammary tumor of C/sub 3/H/He mouse, subcutaneously inoculated in the leg were examined. The effect of FDA plus carbogen, and carbogen alone on radiosensitivity of SCC VII and RIF-I tumors was tested using the in vivo-in vitro assay. The growth curves were obtained for both SCC VII tumor and transplanted mammary tumor. The effect of the combination of FDA and carbogen was only observed in the transplanted mammary tumor. In the other two tumors, only the effect of inspiring carbogen was observed. We concluded that the effect of FDA on the radiosensitivity of experimental tumors varies with the kind of tumor systems.

• Research Organization: Kyoto Univ. (Japan)
• OSTI ID: 6067940
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 16:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NEOPLASMS
RADIOSENSITIVITY
RADIOSENSITIZERS
EVALUATION
BIOASSAY
CARBON DIOXIDE
EXPERIMENTAL NEOPLASMS
GROWTH
MICE
OXYGEN
RADIOSENSITIVITY EFFECTS
ANIMALS
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
DISEASES
DRUGS
ELEMENTS
MAMMALS
NONMETALS
OXIDES
OXYGEN COMPOUNDS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals