Chemical induction of cancer: structural bases and biological mechanisms. Volume IIIB. Aliphatic and polyhalogenated carcinogens

Book · Tue Jan 01 04:00:00 UTC 1985

OSTI ID:6059348

Woo, Y; Lai, D Y; Arcos, J C; Argus, M F ^[1]

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1. eds.

The book reviewed is the fifth in a series entitled Chemical Induction of Cancer. It describes the structure-activity relationships of a wide range of chemicals: haloalkanes and alkenes (conjugated and unconjugated) and their cyclic analogs; polyhalogenated aromatic hydrocarbons and their ethers; and miscellaneous halogenated organics. In addition, an appendix has been added which includes novel types of carcinogens. A discussion of environmental effects is given; i.e., sources, extent of exposure, distribution and environmental persistence. Recent advances in chemical carcinogenesis are described including: (1) the molecular biology of the chemical induction of oncogenes or other processes which affect gene expression and (2) prediction of carcinogenicity by the use of computerized methodologies.

• OSTI ID: 6059348
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
CARCINOGENESIS
ENVIRONMENTAL IMPACTS
GENES
HALOGENATED ALIPHATIC HYDROCARBONS
HALOGENATED AROMATIC HYDROCARBONS
MOLECULAR BIOLOGY
ONCOGENES
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOGENESIS
STRUCTURE-ACTIVITY RELATIONSHIPS