Early phenotype expression of cortical neurons: Evidence that a subclass of migrating neurons have callosal axons
Journal Article
·
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
- Yale Univ. School of Medicine, New Haven, CT (USA)
The use of ({sup 3}H)thymidine labeling in combination with various axonal transport tracers has revealed that a subset of migrating neurons in the fetal monkey cerebrum issue axons to the opposite cerebral hemisphere while still migrating to their final positions in the cortical plate. Other cortical neurons with the same birthdate (i.e., that underwent their last round of DNA synthesis on the same day) are not retrogradely labeled by tracer injections of the opposite hemisphere. These findings suggest that the cardinal distinction between projection and local circuit neurons may be specified in postmitotic neurons before they acquire their final positions in the cortex.
- OSTI ID:
- 6058907
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 88:4; ISSN 0027-8424
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
NERVE CELLS
TISSUE DISTRIBUTION
AUTORADIOGRAPHY
DNA REPLICATION
FETUSES
MONKEYS
PHENOTYPE
THYMIDINE
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
AZINES
DISTRIBUTION
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
MAMMALS
NUCLEIC ACID REPLICATION
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRIMATES
PYRIMIDINES
RIBOSIDES
SOMATIC CELLS
VERTEBRATES
551000* - Physiological Systems
NERVE CELLS
TISSUE DISTRIBUTION
AUTORADIOGRAPHY
DNA REPLICATION
FETUSES
MONKEYS
PHENOTYPE
THYMIDINE
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
AZINES
DISTRIBUTION
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
MAMMALS
NUCLEIC ACID REPLICATION
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRIMATES
PYRIMIDINES
RIBOSIDES
SOMATIC CELLS
VERTEBRATES
551000* - Physiological Systems