Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals

Journal Article · Mon Jul 15 00:00:00 EDT 1991 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.88.14.6107· OSTI ID:6056213

Kihara, Mikihiro; Schmelzer, J D; Poduslo, J F; Curran, G L; Nickander, K K; Low, P A ^[1]

---

1. Mayo Foundation, Rochester, MN (United States)

Since advanced glycosylation end products have been suggested to mediate hyperglycemia-induced microvascular atherogenesis and because aminoguanidine (AG) prevents their generation, the authors examined whether AG could prevent or ameliorate the physiologic and biochemical indices of streptozotocin (STZ)-induced experimental diabetic neuropathy. Four groups of adult Sprague-Dawley rats were studied: group I received STZ plus AG, group II received STZ plus AG, group III received STZ alone, and group IV was a control. They monitored conduction and action potential amplitudes serially in sciatic-tibial and caudal nerves, nerve blood flow, oxygen free radical activity (conjugated dienes and hydroperoxides), and the product of the permeability coefficient and surface area to {sup 125}I-labeled albumin. STZ-induced diabetes (group III) caused a 57% reduction in nerve blood flow and in abnormal nerve conduction and amplitudes and a 60% increase in conjugated dienes. Nerve blood flow was normalized by 8 weeks with AG (groups I and II) and conduction was significantly improved, in a dose-dependent manner, by 16 and 24 weeks in sciatic-tibial and caudal nerves, respectively. The permeability coefficient was not impaired, suggesting a normal blood-nerve barrier function for albumin, and the oxygen free-radical indices were not ameliorated by AG. They suggest that AG reverses nerve ischemia and more gradually improves their electrophysiology by an action on nerve microvessels. AG may have potential in the treatment of diabetic neuropathy.

• OSTI ID: 6056213
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Vol. 88:14; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD FLOW
PHYSIOLOGY
GUANIDINES
BIOLOGICAL EFFECTS
SCIATIC NERVE
PERMEABILITY
DIABETES MELLITUS
GLUCOSE
IODINE 125
IODINE 131
NERVES
RATS
STREPTOZOCIN
SUPEROXIDE RADICALS
ALDEHYDES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOHYDRATES
CARBONIC ACID DERIVATIVES
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE DISEASES
HEXOSES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
ISOTOPES
MAMMALS
METABOLIC DISEASES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADICALS
RADIOISOTOPES
RODENTS
SACCHARIDES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques