The effect of nifedipine on myocardial perfusion and metabolism in systemic sclerosis. A positron emission tomographic study

Journal Article · Fri Feb 01 00:00:00 EST 1991 · Arthritis and Rheumatism; (USA)

DOI:https://doi.org/10.1002/art.1780340211· OSTI ID:6055396

Duboc, D; Kahan, A; Maziere, B; Loc'h, C; Crouzel, C; Menkes, C J; Amor, B; Strauch, G; Guerin, F; Syrota, A ^[1]

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1. S. H. Frederic Joliot, CEA, Orsay (France)

We assessed the effect of nifedipine on myocardial perfusion and metabolism in 9 patients with systemic sclerosis, using positron emission tomography with a perfusion tracer (potassium-38) and a metabolic tracer (18F-fluorodeoxyglucose (18FDG)). Nifedipine, 20 mg 3 times daily for 1 week, induced a significant increase in 38K myocardial uptake, a significant decrease in 18FDG myocardial uptake, and a significant increase in the myocardial 38K: 18FDG ratio. These results indicate that the increase in myocardial perfusion is associated with modifications in myocardial energy metabolism, which probably result from a beneficial anti-ischemic effect of nifedipine in patients with systemic sclerosis.

• OSTI ID: 6055396
• Journal Information: Arthritis and Rheumatism; (USA), Vol. 34:2; ISSN 0004-3591
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARDIOVASCULAR DISEASES
DIAGNOSIS
MYOCARDIUM
POSITRON COMPUTED TOMOGRAPHY
VASODILATORS
BIOLOGICAL EFFECTS
FLUORINE 18
GLUCOSE
METABOLISM
PATIENTS
POTASSIUM 38
ALDEHYDES
ALKALI METAL ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HEART
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
MUSCLES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
POTASSIUM ISOTOPES
RADIOISOTOPES
SACCHARIDES
SECONDS LIVING RADIOISOTOPES
TOMOGRAPHY
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