Sodium-22 influx into erythrocytes from diabetic hypertensive patients on maintenance hemodialysis

Journal Article · Mon Oct 01 00:00:00 EDT 1990 · Journal of the National Medical Association; (USA)

OSTI ID:6054466

Gambhir, K K; Mathews, J; Parui, R; Cruz, I A; Hosten, A O; Dillard, M G ^[1]

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1. Howard Univ. Hospital, Washington, DC (USA)

We have studied the percentage of 22Na+ uptake in cell suspensions; 0.4 to 2.0 x 10(9) erythrocytes/mL from diabetic uremic patients with secondary hypertension and from normal subjects. Suspensions from diabetic uremic patients with secondary hypertension 0.42 +/- 0.06 to 2.05 +/- 0.28; normal subjects showed a percentage uptake of 22Na+ of 0.27 +/- 0.05 to 1.28 +/- 0.22. The uptake of 22Na+ in 2.0 x 10(9) cells/mL was 60% more (P less than .05) in diabetic uremic patients than in the controls. These studies indicate that 22Na+ influx determinations may be used to distinguish secondary hypertensive patients from normal subjects.

• OSTI ID: 6054466
• Journal Information: Journal of the National Medical Association; (USA), Vol. 82:10; ISSN 0027-9684
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DIABETES MELLITUS
PATHOGENESIS
HYPERTENSION
BIOLOGICAL MARKERS
SODIUM COMPOUNDS
UPTAKE
DIALYSIS
ERYTHROCYTES
PATIENTS
SODIUM 22
TRACER TECHNIQUES
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARDIOVASCULAR DISEASES
DISEASES
ENDOCRINE DISEASES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MATERIALS
METABOLIC DISEASES
NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPES
SEPARATION PROCESSES
SODIUM ISOTOPES
SYMPTOMS
VASCULAR DISEASES
YEARS LIVING RADIOISOTOPES
550901* - Pathology- Tracer Techniques