/sup 76/Br-bromospiroperidol: a new tool for quantitative in-vivo imaging of neuroleptic receptors

Journal Article · Mon Sep 24 00:00:00 EDT 1984 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(84)90391-6· OSTI ID:6053686

Maziere, B; Loc'h, C; Hantraye, P; Guillon, R; Duquesnoy, N; Soussaline, F; Naquet, R; Comar, D; Maziere, M

Bromine-76 labeled bromospiperone has been prepared with a very high specific activity (>1 Ci/..mu..mole). In-vivo studies in rat correborated by PET studies in baboon have shown that the regional concentration of this radioligand parallels the morphologic distribution of dopamine receptors and that its binding in the striatum is saturable and displaceable. Tomographic images show a clear delineation of the stratial region 2.5 hours after administration of the radioligand.

• Research Organization: Service Hospitalier Frederic Joliot, Orsay, France
• OSTI ID: 6053686
• Journal Information: Life Sci.; (United States), Vol. 35:13
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BROMINE 76
TRACER TECHNIQUES
RECEPTORS
TOMOGRAPHY
APES
BIOLOGICAL LOCALIZATION
CHEMICAL BONDS
DOPAMINE
IN VIVO
LABELLED COMPOUNDS
LIGANDS
MUSCLES
RATS
SYMPATHOMIMETICS
TRANQUILIZERS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BROMINE ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM AGENTS
DIAGNOSTIC TECHNIQUES
DRUGS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PRIMATES
PSYCHOTROPIC DRUGS
RADIOISOTOPES
RODENTS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics