Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zona pellucida protein
Journal Article
·
· Science (Washington, D.C.); (United States)
The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal antibodies demonstrate a remarkably high target-to-nontarget tissue ratio and provide clear external radioimaging of ovarian tissue.
- Research Organization:
- National Inst. of Arthritis, Bethesda, MD
- OSTI ID:
- 6053612
- Journal Information:
- Science (Washington, D.C.); (United States), Vol. 225:4665
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
MONOCLONAL ANTIBODIES
DIAGNOSTIC USES
OVARIES
SCINTISCANNING
IODINE 125
MICE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
FEMALE GENITALS
GONADS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
MONOCLONAL ANTIBODIES
DIAGNOSTIC USES
OVARIES
SCINTISCANNING
IODINE 125
MICE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
FEMALE GENITALS
GONADS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics