Modifications of lung clearance mechanisms by acute influenza A infection
Abstract
Four volunteers with naturally acquired, culture-proved influenza A infection inhaled a radiolabeled aerosol to permit investigation of lung mucociliary clearance mechanisms during and after symptomatic illness. Mucus transport in the trachea was undetectable when monitored with an external multidetector probe within 48 hours of the onset of the illness, but was found at a normal velocity by 1 week in three of the four subjects. In two volunteers who coughed 23 to 48 times during the 4.5-hour observation period, whole lung clearance was as fast within the first 48 hours of illness as during health 3 months later in spite of the absence of measurable tracheal mucus transport. Conversely, in spite of the return 1 week later of mucus transport at velocities expected in the trachea, whole lung clearance for the 4.5-hour period was slowed in two volunteers who coughed less than once an hour. The data offer evidence that cough is important in maintaining lung clearance for at least several days after symptomatic influenza A infection when other mechanisms that depend on ciliary function are severely deficient.
- Authors:
- Publication Date:
- Research Org.:
- Univ. of Illinois College of Medicine, Chicago
- OSTI Identifier:
- 6043827
- Resource Type:
- Journal Article
- Journal Name:
- J. Lab. Clin. Med.; (United States)
- Additional Journal Information:
- Journal Volume: 4
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOACTIVE AEROSOLS; INHALATION; LUNG CLEARANCE; RESPIRATORY SYSTEM; RADIOISOTOPE SCANNING; INFLUENZA; INFLUENZA VIRUSES; ISOMERIC NUCLEI; TECHNETIUM 99; TRACHEA; AEROSOLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CLEARANCE; COLLOIDS; COUNTING TECHNIQUES; DISEASES; DISPERSIONS; EXCRETION; HOURS LIVING RADIOISOTOPES; INFECTIOUS DISEASES; INTAKE; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MICROORGANISMS; NUCLEI; ODD-EVEN NUCLEI; PARASITES; RADIOISOTOPES; SOLS; TECHNETIUM ISOTOPES; VIRAL DISEASES; VIRUSES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
Citation Formats
Levandowski, R A, Gerrity, T R, and Garrard, C S. Modifications of lung clearance mechanisms by acute influenza A infection. United States: N. p., 1985.
Web.
Levandowski, R A, Gerrity, T R, & Garrard, C S. Modifications of lung clearance mechanisms by acute influenza A infection. United States.
Levandowski, R A, Gerrity, T R, and Garrard, C S. 1985.
"Modifications of lung clearance mechanisms by acute influenza A infection". United States.
@article{osti_6043827,
title = {Modifications of lung clearance mechanisms by acute influenza A infection},
author = {Levandowski, R A and Gerrity, T R and Garrard, C S},
abstractNote = {Four volunteers with naturally acquired, culture-proved influenza A infection inhaled a radiolabeled aerosol to permit investigation of lung mucociliary clearance mechanisms during and after symptomatic illness. Mucus transport in the trachea was undetectable when monitored with an external multidetector probe within 48 hours of the onset of the illness, but was found at a normal velocity by 1 week in three of the four subjects. In two volunteers who coughed 23 to 48 times during the 4.5-hour observation period, whole lung clearance was as fast within the first 48 hours of illness as during health 3 months later in spite of the absence of measurable tracheal mucus transport. Conversely, in spite of the return 1 week later of mucus transport at velocities expected in the trachea, whole lung clearance for the 4.5-hour period was slowed in two volunteers who coughed less than once an hour. The data offer evidence that cough is important in maintaining lung clearance for at least several days after symptomatic influenza A infection when other mechanisms that depend on ciliary function are severely deficient.},
doi = {},
url = {https://www.osti.gov/biblio/6043827},
journal = {J. Lab. Clin. Med.; (United States)},
number = ,
volume = 4,
place = {United States},
year = {Tue Oct 01 00:00:00 EDT 1985},
month = {Tue Oct 01 00:00:00 EDT 1985}
}