Genetically determined differences in ethanol sensitivity influenced by body temperature during intoxication
The present study investigated the importance of body temperature during intoxication in mediating differences between five inbred strains of mice (C57BL/6J; BALB/cJ; DBA/2J; A/HeJ; 129/J) in their acute sensitivity to the hypnotic effects of ethanol. Mice exposed to 22/degrees/C after ethanol injection became hypothermic and exhibited statistically significant differences between strains in rectal temperatures at the return of the righting reflex (RORR), duration of loss of the righting reflex (LORR), and blood and brain ethanol concentrations at RORR. Exposure to 34/degrees/C after injection offset ethanol-hypothermia and markedly reduced strain-related differences in rectal temperatures and blood and brain ethanol concentrations at RORR. Brain ethanol concentrations at RORR were significantly lower in C57, BALB, DBA and A/He mice exposed to 34/degrees/C compared to mice exposed to 22/degrees/C during intoxication suggesting that offsetting hypothermia increased ethanol sensitivity in these strains. Taken with previous in vitro studies, these results suggest that genetically determined differences in acute sensitivity to the behavioral effects of ethanol reflect differences in body temperature during intoxication as well as differences in sensitivity to the initial actions of ethanol at the cellular level.
- Research Organization:
- Univ. of Southern California, Los Angeles (USA)
- OSTI ID:
- 6043316
- Journal Information:
- Life Sci.; (United States), Vol. 43:24
- Country of Publication:
- United States
- Language:
- English
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ETHANOL
TOXICITY
MICE
SENSITIVITY
BEHAVIOR
BLOOD
BODY TEMPERATURE
BRAIN
GENETIC VARIABILITY
HYPOTHERMIA
TEMPERATURE DEPENDENCE
ALCOHOLS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL VARIABILITY
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
HYDROXY COMPOUNDS
MAMMALS
MATERIALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology