Effects of liver damage induced by polychlorinated biphenyls (PCB) on cadmium metabolism in mice

Journal Article · Sun Dec 01 00:00:00 EST 1985 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(85)90086-6· OSTI ID:6037657

Andersen, O; Lingegaard, P; Unger, M; Nordberg, G F

Polychlorinated biphenyls (PCB) were added to the diets of mice at different concentrations. Mice fed these diets were given a sc or oral doses of ZCd. The uptake and excretion of Cd was followed by whole-body counting. The gastrointestinal absorption of Cd after an oral dose of ZCd was less in animals fed on 66 ppm PCB diet, compared with a control group, and the body elimination of Cd was faster. In the liver, the amount of Cd was reduced by dietary PCB exposure, after both oral and sc administration of ZCd, and the data suggest a faster transport of Cd from liver to kidneys in PCB-exposed animals than in controls. The mobilized liver Cd was not quantitatively recovered in the kidneys, thus increased urinary excretion due to PCB exposure may have taken place. Histological examination of the livers revealed a dose-dependent induction of liver changes characterized by centrilobular enlargement of liver cells and centrilobular focal necroses. In four of eight livers from animals fed 200 ppm PCB for 32 weeks there were five liver cell tumors with cytological signs of malignancy. In the control group and in groups fed lower doses of PCB (10-100 ppm) no such tumors were found among 28 animals. The results support observations made with agents inducing acute liver damage, that liver damage increases the rate of redistribution of cadmium from the liver to the kidney.

• Research Organization: Odense Univ., Denmark
• OSTI ID: 6037657
• Journal Information: Environ. Res.; (United States), Vol. 38:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CADMIUM
METABOLISM
TISSUE DISTRIBUTION
CHLORINATED AROMATIC HYDROCARBONS
TOXICITY
LIVER
NEOPLASMS
PATHOLOGICAL CHANGES
CADMIUM 109
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
KIDNEYS
MICE
NECROSIS
ORAL ADMINISTRATION
SUBCUTANEOUS INJECTION
TRACER TECHNIQUES
WHOLE-BODY COUNTING
ANIMALS
AROMATICS
BETA DECAY RADIOISOTOPES
BODY
CADMIUM ISOTOPES
COUNTING TECHNIQUES
DATA
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
NUCLEI
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques