Pulmonary metabolism of foreign compounds: Its role in metabolic activation

Journal Article · Sun Apr 01 00:00:00 EST 1990 · Environmental Health Perspectives; (USA)

DOI:https://doi.org/10.2307/3430663· OSTI ID:6034556

Cohen, G M ^[1]

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1. Univ. of London (England)

The lung has the potential of metabolizing many foreign chemicals to a vast array of metabolites with different pharmacological and toxicological properties. Because many chemicals require metabolic activation in order to exert their toxicity, the cellular distribution of the drug-metabolizing enzymes in a heterogeneous tissue, such as the lung, and the balance of metabolic activation and deactivation pathways in any particular cell are key factors in determining the cellular specificity of many pulmonary toxins. Environmental factors such as air pollution, cigarette smoking, and diet markedly affect the pulmonary metabolism of some chemicals and, thereby, possibly affect their toxicity.

• OSTI ID: 6034556
• Journal Information: Environmental Health Perspectives; (USA), Vol. 85; ISSN 0091-6765
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
LUNGS
BIOLOGICAL PATHWAYS
POLYCYCLIC AROMATIC HYDROCARBONS
METABOLIC ACTIVATION
ALKYLATION
BENZOPYRENE
ENZYME ACTIVITY
METABOLITES
METHYL TRANSFERASES
OXIDOREDUCTASES
PHARMACOLOGY
XENOBIOTICS
AROMATICS
BODY
CHEMICAL REACTIONS
CONDENSED AROMATICS
ENZYMES
HYDROCARBONS
ORGANIC COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
TRANSFERASES
560300* - Chemicals Metabolism & Toxicology
550201 - Biochemistry- Tracer Techniques