Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.4040651· OSTI ID:6031422

Alkana, R L; Finn, D A; Galleisky, G G; Syapin, P J; Malcolm, R D

Mice were fed an ethanol-containing liquid diet for 9 days. On removal of the diet, exposure to 12 atmospheres absolute of a mixture of helium and oxygen precipitated earlier withdrawal, increased withdrawal scores for the first 6 hours, and increased the peak withdrawal intensity compared to dependent animals exposed to control conditions. The enhanced withdrawal did not appear to reflect alterations in ethanol elimination, oxygen or helium partial pressures, body temperature, or general excitability. These results extend to chronically treated animals the evidence that hyperbaric exposure antagonizes the membrane actions of ethanol.

• Research Organization: Univ. of Southern California, Los Angeles
• OSTI ID: 6031422
• Journal Information: Science (Washington, D.C.); (United States), Vol. 229
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ETHANOL
BIOLOGICAL EFFECTS
CHRONIC EXPOSURE
HELIUM
INGESTION
MICE
OXYGEN
ALCOHOLS
ANIMALS
ELEMENTS
FLUIDS
GASES
HYDROXY COMPOUNDS
INTAKE
MAMMALS
NONMETALS
ORGANIC COMPOUNDS
RARE GASES
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)