Juvenile Gaucher disease simulating osteomyelitis

Journal Article · Thu Oct 01 00:00:00 EDT 1981 · AJR, Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.137.4.880· OSTI ID:6028568

Miller, J H; Ortega, J A; Heisel, M A

A case in which several imaging procedures suggested juvenile Gaucher disease in a child who presented with symptomatology of osteomyelitis is discussed. The 20-month girl was given a Technetium-99m radionuclide skeletal examination which revealed intense uptake of tracer agents along the shaft of the right femur. It was also found that the liver and spleen were dramatically Ga-67 avid. The bone pain symptomatology suggested an osteomyelitis of the femur, but skeletal scintigraphy with Tc-99m-labeled bone tracer demonstrated photopenic areas involving the femur, suggesting that the bone pain may have been due to marrow packed with Gaucher cells. This overexpansion of the marrow may lead to microfractures with remodeling seen radiographically as periosteal new bone and scintigraphically as increased periosteal deposition of tracer agent. The radiogallium study was useful to exclude an underlying osteomyelitis in the involved femurs. Although juvenile Gaucher disease is unusual, it should be considered in any child who presents with the constellation of hepatosplenomegaly and bone pain simulating osteomyelitis.

• Research Organization: Univ. of Southern California, Los Angeles, CA (United States)
• OSTI ID: 6028568
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Vol. 137:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW
SCINTISCANNING
GALLIUM 67
OSTEOMYELITIS
DIAGNOSIS
TECHNETIUM 99
BONE FRACTURES
FEMUR
ISOMERIC NUCLEI
LIVER
METABOLIC DISEASES
PATIENTS
SPLEEN
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
GLANDS
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INJURIES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SKELETAL DISEASES
SKELETON
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOISOTOPES
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