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Title: Relationship between beta-adrenoceptors and coronary blood flow heterogeneity

Abstract

The purpose of this study was to investigate the hypothesis that the heterogeneous distribution of ..beta.. adrenoceptors contributes to the control of flow heterogeneity in the canine myocardium. ..beta.. adrenoceptor density and affinity were measured simultaneously with coronary blood flow in multiple sections of the left ventricle of 14 anesthetized open chest dogs. Radioactive microspheres were used for the measurement of blood flow. Receptor density (Bmax) and dissociation constant (Kd) were measured using (/sup 125/I)- iodopindolol. The average control myocardial blood flow (MBF) was 86/+-/15 ml/min/100 g. Isoproterenol increased MBF by 82%, whereas propranolol reduced MBF by 13%. The mean value of Bmax was unaltered by either treatment. Under control conditions, a significant positive positive correlation was observed between Bmax and blood flow. In the isoproterenol treatment group, this correlation was enhanced. Beta adrenoceptor blockade led to a negative correlation. Kd showed no overall correlation with blood flow. Kd but not Bmax was significantly higher in the EPI than in the ENDO and in the base compared to the apex. There appears to be a direct linear relationship between the distribution of beta adrenoceptors and MBF distribution which is enhanced under conditions of high beta adrenergic activity. There is amore » correlation between beta adrenoceptor activity and blood flow distribution in the canine myocardium.« less

Authors:
;
Publication Date:
Research Org.:
Robert Wood Johnson Medical School, Piscataway, NJ (USA)
OSTI Identifier:
6025049
Resource Type:
Journal Article
Journal Name:
Life Sci.; (United States)
Additional Journal Information:
Journal Volume: 44:17
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; MYOCARDIUM; BLOOD FLOW; RECEPTORS; SUBCELLULAR DISTRIBUTION; SYMPATHOMIMETICS; CORONARIES; DOGS; IODINE 125; MICROSPHERES; TRACER TECHNIQUES; VASODILATORS; ANIMALS; ARTERIES; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR AGENTS; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEART; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MEMBRANE PROTEINS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; VERTEBRATES; 551001* - Physiological Systems- Tracer Techniques

Citation Formats

Upsher, M E, and Weiss, H R. Relationship between beta-adrenoceptors and coronary blood flow heterogeneity. United States: N. p., 1989. Web. doi:10.1016/0024-3205(89)90312-3.
Upsher, M E, & Weiss, H R. Relationship between beta-adrenoceptors and coronary blood flow heterogeneity. United States. https://doi.org/10.1016/0024-3205(89)90312-3
Upsher, M E, and Weiss, H R. 1989. "Relationship between beta-adrenoceptors and coronary blood flow heterogeneity". United States. https://doi.org/10.1016/0024-3205(89)90312-3.
@article{osti_6025049,
title = {Relationship between beta-adrenoceptors and coronary blood flow heterogeneity},
author = {Upsher, M E and Weiss, H R},
abstractNote = {The purpose of this study was to investigate the hypothesis that the heterogeneous distribution of ..beta.. adrenoceptors contributes to the control of flow heterogeneity in the canine myocardium. ..beta.. adrenoceptor density and affinity were measured simultaneously with coronary blood flow in multiple sections of the left ventricle of 14 anesthetized open chest dogs. Radioactive microspheres were used for the measurement of blood flow. Receptor density (Bmax) and dissociation constant (Kd) were measured using (/sup 125/I)- iodopindolol. The average control myocardial blood flow (MBF) was 86/+-/15 ml/min/100 g. Isoproterenol increased MBF by 82%, whereas propranolol reduced MBF by 13%. The mean value of Bmax was unaltered by either treatment. Under control conditions, a significant positive positive correlation was observed between Bmax and blood flow. In the isoproterenol treatment group, this correlation was enhanced. Beta adrenoceptor blockade led to a negative correlation. Kd showed no overall correlation with blood flow. Kd but not Bmax was significantly higher in the EPI than in the ENDO and in the base compared to the apex. There appears to be a direct linear relationship between the distribution of beta adrenoceptors and MBF distribution which is enhanced under conditions of high beta adrenergic activity. There is a correlation between beta adrenoceptor activity and blood flow distribution in the canine myocardium.},
doi = {10.1016/0024-3205(89)90312-3},
url = {https://www.osti.gov/biblio/6025049}, journal = {Life Sci.; (United States)},
number = ,
volume = 44:17,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1989},
month = {Sun Jan 01 00:00:00 EST 1989}
}