Radiation-induced volatile hydrocarbon production in platelets

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(89)90313-5· OSTI ID:6023903

Radha, E; Vaishnav, Y N; Kumar, K S; Weiss, J F

Generation of volatile hydrocarbons (ethane, pentane) as a measure of lipid peroxidation was followed in preparations from platelet-rich plasma irradiated in vitro. The hydrocarbons in the headspace of sealed vials containing irradiated and nonirradiated washed platelets, platelet-rich plasma, or platelet-poor plasma increased with time. The major hydrocarbon, pentane, increased linearly and significantly with increasing log radiation dose, suggesting that reactive oxygen species induced by ionizing radiation result in lipid peroxidation. Measurements of lipid peroxidation products may give an indication of suboptimal quality of stored and/or irradiated platelets.

• Research Organization: Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
• OSTI ID: 6023903
• Journal Information: Life Sci.; (United States), Vol. 44:17
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD PLATELETS
BIOLOGICAL RADIATION EFFECTS
ETHANE
BIOSYNTHESIS
LIPIDS
METABOLISM
PENTANE
BLOOD PLASMA
DOSE-RESPONSE RELATIONSHIPS
IONIZING RADIATIONS
RADIOINDUCTION
VOLATILE MATTER
ALKANES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
HYDROCARBONS
MATERIALS
MATTER
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
SYNTHESIS
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture