Synergistic interaction between nitrogen dioxide and respirable aerosols of sulfuric acid or sodium chloride on rat lungs

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(87)90303-6· OSTI ID:6017078

Last, J A; Warren, D L

We examined interactions in rats between NO/sub 2/ gas and respirable aerosols of sulfuric acid (H/sub 2/SO/sub 4/) or sodium chloride (NaCl). Rats were exposed for 1, 3, or 7 days to 5 ppm of NO/sub 2/ gas, alone or in combination with 1 mg/m3 of H/sub 2/SO/sub 4/ or NaCl aerosols. The apparent rate of collagen synthesis by lung minces was measured after 7 days of exposure, and the protein content of whole lung lavage fluid was measured after 1 or 3 days of exposure. Responses from rats exposed to 5 ppm of NO/sub 2/ alone were significantly different from controls by these assays. A synergistic interaction was demonstrated between 5 ppm of NO/sub 2/ and 1 mg/m3 of either H/sub 2/SO/sub 4/ or NaCl aerosol as evaluated by measurement of the rate of lung collagen synthesis. A synergistic interaction was also demonstrated by the criterion of increased protein content of lung lavage fluid in rats exposed to 5 ppm of NO/sub 2/ and 1 mg/m3 of H/sub 2/SO/sub 4/ aerosol after 1 day of exposure and between 5 ppm of NO/sub 2/ and 1 mg/m3 of NaCl aerosol after 3 days of exposure. These observations with 5 ppm of NO/sub 2/ alone and in combination with 1 mg/m3 of NaCl aerosol support the hypothesis that formation of nitrosyl chloride may contribute to a synergistic interaction between NO/sub 2/ gas and NaCl aerosol. These results suggest that, in general, combinations of oxidant gases with respirable acidic aerosols or with acidogenic gases will demonstrate interactive effects on rat lungs. Such a hypothesis is testable and makes specific predictions about effects of inhalation of pollutant mixtures.

• Research Organization: Univ. of California, Davis
• OSTI ID: 6017078
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Vol. 90:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COLLAGEN
BIOSYNTHESIS
NITROGEN DIOXIDE
BIOLOGICAL EFFECTS
SODIUM CHLORIDES
SULFURIC ACID
ACID PHOSPHATASE
AEROSOLS
INHALATION
LACTATE DEHYDROGENASE
LAVAGE
LUNGS
OZONE
RATS
SYNERGISM
ALKALI METAL COMPOUNDS
ANIMALS
BODY
CHALCOGENIDES
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
DISPERSIONS
ENZYMES
ESTERASES
HALIDES
HALOGEN COMPOUNDS
HEMIACETAL DEHYDROGENASES
HYDROGEN COMPOUNDS
HYDROLASES
INORGANIC ACIDS
INTAKE
MAMMALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PHOSPHATASES
PROTEINS
RESPIRATORY SYSTEM
RODENTS
SCLEROPROTEINS
SODIUM COMPOUNDS
SOLS
SYNTHESIS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology