Two methods of preparation of xenon-133 saline solution
Two procedures for dissolving /sup 133/Xe gas in isotonic saline simply and economically with reasonably high activity concentrations are described. The first method is a modification of a previously described procedure and introduces a new flow-through mixing system allowing for a more homogeneous preparation. This system can be used with significant cost and time savings in a department with large clinical demand (> 3 patients per week). The second method is a system which can be used economically in a department with a small and/or sporadic clinical demand. This technique involves the preparation of single-patient dose by introducing saline into commercially available /sup 133/Xe gas vials. The solubility of /sup 133/Xe in saline can be significantly increased (> 50%) by introducing saline into a /sup 133/Xe gas vial and incubating the reactive vial at 4 /sup 0/C for 3 hr or more. The suggested modifications are simple and the resultant activity concentrations are relatively high and clinically useful.
- Research Organization:
- Univ. of Illinois, Chicago
- OSTI ID:
- 6011640
- Journal Information:
- J. Nucl. Med. Technol.; (United States), Vol. 14:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
AQUEOUS SOLUTIONS
BLOOD FLOW
CEREBRUM
PATIENTS
SALINITY
SOLUBILITY
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISPERSIONS
DRUGS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MIXTURES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
SOLUTIONS
SYNTHESIS
XENON ISOTOPES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials