Dosimetric estimates for clinical positron emission tomographic scanning after injection of ( sup 18 F)-6-fluorodopamine

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:6005592

Goldstein, D S; Chang, P C; Smith, C B; Herscovitch, P; Austin, S M; Eisenhofer, G; Kopin, I J ^[1]

---

1. National Heart, Lung, and Blood Institute, Bethesda, MD (USA)

Positron emission tomographic (PET) scanning after systemic i.v. injection of fluorine-18-6-fluorodopamine (({sup 18}F)-6F-DA) is a method for visualizing and measuring regional sympathetic nervous system innervation and function. Based on results of preclinical studies of rats and dogs and on previous literature about the fate of injected tracer-labeled catecholamines, dosimetric estimates for clinical studies are presented here. After injection of 1 mCi of ({sup 18}F)-F-DA, the radiation dose would be highest to the wall of the urinary bladder (1.40 rem/mCi), due to accumulation of radioactive metabolites of ({sup 18}F)-F-DA in urine. Radioactivity also would accumulate in bile. Organs receiving the next highest dose would be the kidneys (0.9 rem/mCi) and small intestine (0.2 rem/mCi). The parenchymal radiation dose would be lowest in the brain, since there is an effective blood-brain barrier for circulating catecholamines. Radiation doses to all organs after administration of 1 mCi of ({sup 18}F)-F-DA to humans would be less than 3 rem and, therefore, within current FDA guidelines.

• OSTI ID: 6005592
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 32:1; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
AUTONOMIC NERVOUS SYSTEM
DYNAMIC FUNCTION STUDIES
ORGANS
RADIATION DOSES
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
DOGS
DOPAMINE
FLUORINE 18
METABOLISM
POSITRON COMPUTED TOMOGRAPHY
RADIONUCLIDE KINETICS
RATS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOSES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
RADIOISOTOPES
RODENTS
SYMPATHOMIMETICS
TOMOGRAPHY
VERTEBRATES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells
550601 - Medicine- Unsealed Radionuclides in Diagnostics