Fetal frontal cortex transplant (/sup 14/C) 2-deoxyglucose uptake and histology: survival in cavities of host rat brain motor cortex

Journal Article · Mon Oct 01 00:00:00 EDT 1984 · Neurology; (United States)

OSTI ID:5999047

Sharp, F R; Gonzalez, M F

Fetal frontal neocortex from 18-day-old rat embryonic brain was transplanted into cavities in 30-day-old host motor cortex. Sixty days after transplantation, 5 of 15 transplanted rats had surviving fetal transplants. The fetal cortex transplants were physically attached to the host brain, completely filled the original cavity, and had numerous surviving cells including pyramidal neurons. Cell lamination within the fetal transplant was abnormal. The (/sup 14/C) 2-deoxyglucose uptake of all five of the fetal neocortex transplants was less than adjacent cortex and contralateral host motor-sensory cortex, but more than adjacent corpus callosum white matter. The results indicate that fetal frontal neocortex can be transplanted into damaged rat motor cortex. The metabolic rate of the transplants suggests they could be partially functional.

• Research Organization: Veterans Administration Medical Center, San Francisco, CA
• OSTI ID: 5999047
• Journal Information: Neurology; (United States), Vol. 34:10
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BRAIN
TRANSPLANTS
GLUCOSE
UPTAKE
SURVIVAL TIME
AUTORADIOGRAPHY
CARBON 14 COMPOUNDS
FETUSES
HISTOLOGY
RATS
TRACER TECHNIQUES
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
HEXOSES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
RODENTS
SACCHARIDES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques