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Title: Radioactive iodine treatment of metastatic thyroid carcinoma with clinical thyrotoxicosis

Abstract

We present a case of well-differentiated follicular carcinoma of the thyroid with hyperfunctioning metastases and clinical thyrotoxicosis. The recommended I-131 treatment dose for patients with widespread bone metastases from thyroid carcinoma is 200 mCi. However, in a patient with hyperfunctioning metastatic tumor and increased radioiodine uptake, the treatment dose should be modified. Radiation dosimetry measurements performed on the patient in this study demonstrated that 132 mCi would be a safe therapeutic I-131 dose which would avoid injury to normal radiosensitive tissues. Consequently, she was given a 130-mCi therapeutic dose.

Authors:
; ; ;
Publication Date:
Research Org.:
Columbia Presbyterian Medical Center, New York, NY
OSTI Identifier:
5998001
Resource Type:
Journal Article
Journal Name:
Clin. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 12
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOMAS; RADIOTHERAPY; THYROID; RADIATION DOSES; HYPERTHYROIDISM; IODINE 131; METASTASES; PATIENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; DOSES; ENDOCRINE DISEASES; ENDOCRINE GLANDS; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; RADIOLOGY; THERAPY; 550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-); 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man

Citation Formats

Smith, R, Blum, C, Benua, R S, and Fawwaz, R A. Radioactive iodine treatment of metastatic thyroid carcinoma with clinical thyrotoxicosis. United States: N. p., 1985. Web. doi:10.1097/00003072-198512000-00011.
Smith, R, Blum, C, Benua, R S, & Fawwaz, R A. Radioactive iodine treatment of metastatic thyroid carcinoma with clinical thyrotoxicosis. United States. https://doi.org/10.1097/00003072-198512000-00011
Smith, R, Blum, C, Benua, R S, and Fawwaz, R A. 1985. "Radioactive iodine treatment of metastatic thyroid carcinoma with clinical thyrotoxicosis". United States. https://doi.org/10.1097/00003072-198512000-00011.
@article{osti_5998001,
title = {Radioactive iodine treatment of metastatic thyroid carcinoma with clinical thyrotoxicosis},
author = {Smith, R and Blum, C and Benua, R S and Fawwaz, R A},
abstractNote = {We present a case of well-differentiated follicular carcinoma of the thyroid with hyperfunctioning metastases and clinical thyrotoxicosis. The recommended I-131 treatment dose for patients with widespread bone metastases from thyroid carcinoma is 200 mCi. However, in a patient with hyperfunctioning metastatic tumor and increased radioiodine uptake, the treatment dose should be modified. Radiation dosimetry measurements performed on the patient in this study demonstrated that 132 mCi would be a safe therapeutic I-131 dose which would avoid injury to normal radiosensitive tissues. Consequently, she was given a 130-mCi therapeutic dose.},
doi = {10.1097/00003072-198512000-00011},
url = {https://www.osti.gov/biblio/5998001}, journal = {Clin. Nucl. Med.; (United States)},
number = ,
volume = 12,
place = {United States},
year = {Sun Dec 01 00:00:00 EST 1985},
month = {Sun Dec 01 00:00:00 EST 1985}
}