Comparison of the effect of sorbitol and glucose on calcium absorption in postmenopausal women

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Am. J. Clin. Nutr.; (United States)

OSTI ID:5997796

Francis, R M; Peacock, M; Barkworth, S A; Marshall, D H

It has been suggested that the oral administration of sorbitol promotes calcium absorption, while glucose has no effect. We have therefore compared the effect of oral sorbitol and glucose on the absorption of radiocalcium from low and high carrier loads in healthy postmenopausal women. In a control group of 20 women given neither sorbitol nor glucose, the mean +/- SEM fractional radiocalcium absorption rate from a low carrier load was 0.65 +/- 0.05 (fraction of dose/h). In a second group of 10 women the fractional absorption rate from the low carrier load was lower (p less than 0.05) with 10 g sorbitol (0.48 +/- 0.05) than with 10 g glucose (0.65 +/- 0.08). Fractional absorption of radiocalcium from a high carrier load measured in a third group of seven women using two isotopes (oral 45Ca, IV 47Ca) was also lower (p less than 0.001) with 10 g sorbitol (0.22 +/- 0.01, fraction/3 h) than with 10 g glucose (0.29 +/- 0.02). The results suggest that calcium absorption from a low carrier load is unaltered by glucose but that absorption of calcium from both low and high carrier loads is lower with sorbitol than with glucose.

• Research Organization: MRC Mineral Metabolism Unit, Leeds, England
• OSTI ID: 5997796
• Journal Information: Am. J. Clin. Nutr.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CALCIUM
INTESTINAL ABSORPTION
SORBITOL
BIOLOGICAL EFFECTS
CALCIUM 45
GLUCOSE
MENOPAUSE
TRACER TECHNIQUES
WOMEN
ABSORPTION
ALDEHYDES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CALCIUM ISOTOPES
CARBOHYDRATES
DAYS LIVING RADIOISOTOPES
DIURETICS
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
FEMALES
HEXOSES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MAN
METALS
MONOSACCHARIDES
NUCLEI
ORGANIC COMPOUNDS
PRIMATES
RADIOISOTOPES
SACCHARIDES
UPTAKE
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques