Clinical correlates of the spectrum of lung microvascular injury in human noncardiac edema

Journal Article · Tue Feb 01 00:00:00 EST 1983 · Crit. Care Med.; (United States)

DOI:https://doi.org/10.1097/00003246-198302000-00003· OSTI ID:5997777

Sibbald, W J; Driedger, A A; Wells, G A; Koval, J J

Researchers measured the clearance from blood to pulmonary edema fluid of a small molecular researchersight hydrophilic radiotracer, Indium-111-DTPA (In-DTPA) and a larger molecular researchrsight radiotracer, Iodine-125-HSA (I-HSA), in patients with pulmonary edema on either a cardiac or noncardiac (permeability) basis. In previous investigations, researchers had noted an apparent relationship between the magnitude of clearance of I-HSA across the alveolocapillary membrane and the severity of noncardiac pulmonary edema. In this study, researchers were able to distinguish at least 2 distinct groups of patients with noncardiac pulmonary edema. Patients with the greatest damage to the alveolo-capillary exchanging membrane, defined by the flux of I-HSA from blood to edema fluid, were significantly differentiated from those with a lesser microvascular injury on the basis of higher mean heart rate (HR), temperature, cardiac index (CI), pulmonary artery pressures, right ventricular stroke work index (RVSWI), and a lower mean total white blood cell count (WBC), among others. Therefore, noncardiac pulmonary edema is characterized by a spectrum of permeability injury to the pulmonary microvasculature which seems to parallel other measurable indices of the severity of the systemic response to the illness.

• Research Organization: Department of Medicine, Victoria Hospital, London, Ontario, Canada
• OSTI ID: 5997777
• Journal Information: Crit. Care Med.; (United States), Vol. 11:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
CAPILLARIES
INJURIES
CELL MEMBRANES
PERMEABILITY
HEART
EDEMA
INDIUM 111
DIAGNOSTIC USES
IODINE 125
BLOOD-PLASMA CLEARANCE
BODY FLUIDS
COMPARATIVE EVALUATIONS
LABELLED COMPOUNDS
LUNGS
PHYSIOLOGY
SCINTISCANNING
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MEMBRANES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SYMPTOMS
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques